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2.A.54.1.6
Sideroflexin-3, Sfxn3 or SLC56A3, of 321 aas and 4 TMSs in a 2 + 2 TMS arrangement. It is an α-synuclein-dependent mitochondrial protein that regulates synaptic morphology (Amorim et al. 2017). It is highly expressed in mature neurons of the mouse, with expression developing as development occurs from birth to adulthood.  Within neurons, Sfxn3 localizes to mitochondria in all major neuronal compartments (Rivell et al. 2019). The human ortholog is 94% identical to the mouse protein.  Association of poly(rC)-binding protein-2 with sideroflexin-3 through TOM20 allows iron entry into mitochondria (Mi et al. 2024).

Accession Number:Q91V61
Protein Name:Sideroflexin-3
Length:321
Molecular Weight:35406.00
Species:Mus musculus (Mouse) [10090]
Number of TMSs:4
Location1 / Topology2 / Orientation3: Mitochondrion membrane1 / Multi-pass membrane protein2
Substrate iron(3+)

Cross database links:

Entrez Gene ID: 94280   
Pfam: PF03820   
KEGG: mmu:94280   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0031966 C:mitochondrial membrane
GO:0005739 C:mitochondrion
GO:0008324 F:cation transmembrane transporter activity
GO:0055072 P:iron ion homeostasis

References (3)

[1] “A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice.”  Fleming M.D.et.al.   11274051
[2] “The transcriptional landscape of the mammalian genome.”  Carninci P.et.al.   16141072
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MGDLPLNINI QEPRWDQSTF LGRARHFFTV TDPRNLLLSG EQLEASRNIV QNYRAGVATP 
61:	GLTEDQLWRA KYVYDSAFHP DTGEKVVLIG RMSAQVPMNM TITGCMLTFY RKTPTVVFWQ 
121:	WVNQSFNAIV NYSNRSGDAP ITVQQLGTAY VSATTGAVAT ALGLKSLTKH LPPLVGRFVP 
181:	FAAVAAANCI NIPLMRQREL QVGIPVTDEA GQRLGHSVTA AKQGIFQVVI SRIGMAIPAM 
241:	AIPPVIMNTL EKKDFLKRRP WLGAPLQVGL VGFCLVFATP LCCALFPQRS SIHVTRLEPE 
301:	LRAQIQAQNP SIDVVYYNKG L