2.A.55.2.10
NRAMP2 (NRAMPB; SLC11a2) of 552 aas and 10 TMSs. Inovoled in iron hoemeostasis and infectivity together with NRAMP1 (TC#2.A.55.2.9). Present in the contractile vacuole which regulates osmolarity and possible stores iron (Peracino et al. 2013). Nramp1 and NrampB (Nramp2) are in membranes of macropinosomes and in
phagosomes or the contractile vacuole network, respectively (Peracino et al. 2022).
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| Accession Number: | Q553K4 |
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| Protein Name: | Natural resistance-associated macrophage protein 2 homolog |
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| Length: | 629 |
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| Molecular Weight: | 70404.00 |
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| Species: | Dictyostelium discoideum (Slime mold) [44689] |
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| Number of TMSs: | 10 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
iron(2+) |
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1: MNNNNNNKKL NKENLNEIEN WNEIELTDYK KQGLDEGTSS NIYLFESNGN VVNGSIEDSP
61: KQQQQQQQQQ QQQQQQQQQQ QQQQQNIISS DEEIEDKPFQ DRDSNIGDGS DIDSSGDSID
121: IENTDYSILV PFEDEENNNG SKSKFSIKKL KSFLGPALFI SVGYMDPGNW ATDLEGGSRF
181: GYQLMWVLLF SNIMALFLQT LVIKLALVTK NDLAQQCRKE YSKTVNIFLW LILELAIIST
241: DLAEVIGTAI GLNILFGLPL IAGVAITSLD TLLFLAIQRW GIRKLELLIL LLLSMITMCF
301: VIELFLSKPI ASEVFSGFVP RLNSDSVMVA TGIVGATTMP HNLFLHGSVV KSRKIPNDRR
361: KSVIKQAYRY NVIDTVLALN CAFFVNIAIL MLAASVFWKS NIQVTELSEA YRLLTKLMDG
421: KLAAVLFGLG LFLAGQSSTI TGTMAGQIVM EGFIKLRIKP WLRRFITRLL AIIPAAIVII
481: VLGDKGTYTL LIISQVLLSI GLPFAVVPLI IFTSSYEIMG EFKNRLSIII INSIIALFII
541: GLNLATIFQL INDFLHNDSI ISKCLTIIFL IPLSIALCCL LLWLIISKIN FFTNLLSKIF
601: NNNNNNNNKN IINNNNNYSG NTINNQTIQ