2.A.57.1.7
The fluorouridine insensitive 1 (Fur1) or Ent3 pyrimidine nucleoside transporter (Traub et al., 2007). AtENT4, AtENT6 and AtENT7). Three paralogs, Ent4, Ent6 and Ent7, exhibited broad substrate specificity and transported the
purine nucleosides adenosine and guanosine, as well as the pyrimidine
nucleosides cytidine and uridine (Wormit et al. 2004). The apparent Km values were in the
range 3-94 μM, and transport was inhibited strongly by
deoxynucleosides, and to a smaller extent by nucleobases.
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| Accession Number: | Q9M0Y3 |
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| Protein Name: | Ent3 |
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| Length: | 418 |
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| Molecular Weight: | 46208.00 |
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| Species: | Arabidopsis thaliana [3702] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
pyrimidine, 5-fluorouridine |
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| RefSeq: |
NP_192421.1
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| Entrez Gene ID: |
825857
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| Pfam: |
PF01733
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| KEGG: |
ath:AT4G05120
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[1] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.” Mayer K.F.X. et.al. 10617198
[2] “Equilibrative nucleoside transporters of Arabidopsis thaliana. cDNA cloning, expression pattern, and analysis of transport activities.” Li G. et.al. 12810710
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1: MADRYENQPP EKLQGKYQAM VVCCILGIGS LVSWNSMLTI ADYYYKVFPD YHPSRVLTLV
61: YQPFALGTIL ILAYHESKIN TRKRNLIGYI LFTISTFLLI VLDLATKGRG GIGPYIGLCA
121: VVASFGLADA TVQGGMIGDL SLMCPELVQS FMGGLAVSGA LTSALRLITK AAFEKTNDGP
181: RKGAMMFLAI STCIELLCVF LYAYVFPKLP IVKYYRRKAA SEGSKTVSAD LAAAGIQNQS
241: DLTDDDSKNQ RLSNKELLIQ NIDYAVNLFL IYVCTLSIFP GFLYENTGQH GLGDWYALVL
301: VAMYNCWDLV GRYTPLVKWL KIENRKLITI AVLSRYLLIP AFYFTAKYGD QGWMIMLISV
361: LGLTNGHLTV CIMTIAPKGY KGPEQNALGN LLVIFLLGGI FAGVALDWLW LIGKKNAF