2.A.6.5.11
CmpL4 of 801 aas and 12 TMSs. Multidrug resistance protein of 801 aas and 12 TMSs. Mutants are
hypersusceptible to multiple antibiotics, have growth deficiencies
in minimal medium and accumulate intracellular trehalose
monocorynomycolates, free corynomycolates, and a previously
uncharacterized corynomycolate-containing lipid. It is inferred that
this transporter exports one or more of these lipids. Evidence for a
pmf-dependent mechanism was obtained (Yang et al. 2014).
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| Accession Number: | Q8NTS1 |
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| Protein Name: | Predicted drug exporters of the RND superfamily |
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| Length: | 801 |
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| Molecular Weight: | 85801.00 |
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| Species: | Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / LMG 3730 / NCIMB 10025) [196627] |
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| Number of TMSs: | 12 |
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| Substrate |
drug |
|---|
1: MAKLLFRLGR WSYNRKWIVI SAWLLILAIV GGLALTMQKG FSNSFTIEDT PSIDATVSLV
61: ENFPDQTNPV TAAGVNVVFQ SPEGTTLDDP QMMTAMDAVV DYIEDNLPDF GGGERFGNPV
121: EVSPALEEMV IEQMTSMGLP EETAAKDAAN LAVLSEDKTI GYTSFNIDVE AAEYVEQKHR
181: DVINEAMQIG EDLGVRVEAG GPAFGDPIQI ETTSEIIGIG IAFIVLIFTF GSLIAAGLPL
241: ITAVIGVGIG ALAIVLATAF TDLNNVTPVL AVMIGLAVGI DYALFILSRY RAEYKRMPRA
301: DAAGMAVGTA GSAVVFAGAT VIIALVALII ADIGFLTAMG ISAAFTVFVA VLIALTFIPA
361: LLGVFGGHAF KGKIPGIGGN PTPKQTWEQA LNRRSKGRSW VKLVQKAPGL VVAVVVLGLG
421: ALTIPAMNLQ LSLPSDSTSN IDTTQRQSAD LMAEGFGAGV NAPFLVIVDT HEVNADSTAL
481: QPLIEAQEPE EGEFDREQAA RFATYMYVTQ TYNSNIDVKN AQIISVNDDF TAAQILVTPY
541: TGPADKETPE LMHVLRAQEA QIEDVTGTEL GTTGFTAVQL DITEQLEDAM PVYLAVVVGL
601: AIFLLILVFR SLLVPLVAGL GFLLSVGAAF GATVLVWQEG FGGFVNTPGP LISFMPIFLI
661: GVTFGLAMDY QVFLVTRMRE HYTHHNGKGQ PGSKYTPVEQ SVIEGFTQGS RVVTAAALIM
721: IAVFVAFIDQ PLPFIKIFGF ALGAGVFFDA FFIRMGLVPA SMFLMGKATW WMPKWLDRIL
781: PSLDIEGTAL EKEWEEKQAA R