2.A.6.5.15
Fatty acid efflux MMPL transporter, FarE, of 829 aas and 12 TMSs in a 1 + 3 + 2 + 1 + 3 + 2 TMS arrangement (Malwal and Oldfield 2021). FarE has the same set of "active-site" residues as those found in the mycobacterial MmpL3s (TC# 2.A.6.5.6), and in the homolog from Trypanosoma cruzi (TC# 2.A.6.5.16).
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| Accession Number: | QWF26000.1 |
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| Protein Name: | QWF26000.1 fatty acid efflux MMPL transporter FarE [Staphylococcus aureus subsp. aureus RN4220] |
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| Length: | 830 |
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| Molecular Weight: | |
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| Species: | Staphylococcus aureus subsp. aureus RN4220 [561307] |
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| Number of TMSs: | 13 |
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| Substrate |
fatty acid |
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1: MAKFLYKMGT FIAKHKWSAV IAWIVIVAAI LIPLATNAPK FDNDIKMTGL ESLDTNKKIE
61: KHFNQDSEKA QIRVVFKTTK DDGIVQPNIT KDIKKTLDDI KKDDKHIDKI SDPYENKQIS
121: KDKTTAFADI TYDVSQTSLK DGSRDNVKSH LKDLRDNHNV QTELTGTGMT STEVGGNSEL
181: VGIIVAFVVL LITFGSVIAA GLPIISALIG LASGVGIISL LTYAFDIPNV TLTLAVMIGL
241: AVGIDYALFI LFRYRQVMKT ETDYIKGIGL AIGTAGSAVV FAGVTVVIAV CGLSLVGIDF
301: LAVMGFASAI SVVFAVLSAL TLLPALISIF HKRIKVNKLQ SKFKKDIDTP WSKFITGNAL
361: AAVLLGLIIL VAAAIPVSHM RLGIPDDGVK PADSTQKKAY DIISDKFGEG FNGQIPMLIN
421: VKDKKDDPQG LQQDLQSVYK DIKDKKNVDI VTPPQMSKDN DYALMVVIPK QGPNAESTND
481: LVHDLRDYHK DAQDKYGFKT EISGQSVINI DMSKKLNEAI PLFASVIVVL AFFLLMIVFR
541: SILIPLKAVL GFVLSLMATL GFTTLVMQDG FMKGLFGIET TGPMLAFLPV ITIGILFGLA
601: MDYEVFLMSR IHEEYSKTGD NDYSIKVGLK ESGPVIVAAA LIMFSVFFAF VFQEDVMIKS
661: MGMALAFGVL FDAFVVRMML IPALTKLFGK GSWYLPAWLN RIIPRVDIEG HALEKYKTVE
721: SQESEAKDSK ETYDTTFKVY PQGATNVSKH QDAHGQDDAH SIVLDDKTMA LYQEVKQQSA
781: SSLFLYDALI DYQNKHQLNS KQQATNIEQL NKNIEKLNQL LEKNLRNKS