2.A.6.5.17
MMPL3-like protein, a fatty acid transporter of 920 aas and 12 TMSs in a 1 + 5 + 1 + 5 TMS arrangement (Malwal and Oldfield 2022). Homologs of MmpL3 contain "MmpL3-like" (MMPL) transmembrane
(TM) domains in many protozoa, including Trypanosoma cruzi, as well as
in the bacterium Staphylococcus aureus, where the fatty acid transporter
FarE (TC#2.A.6.5.15) has the same set of "active-site" residues as those found in the
mycobacterial MmpL3s, and in T. cruzi. There are
strong sequence and predicted structural similarities between the TM
proton-translocation domain seen in the X-ray structures of
mycobacterial MmpL3s and several human as well as fungal lipid
transporters, leading to the proposal that there are similar proteins in
apicomplexan parasites, and in plants. The animal, fungal,
apicomplexan, and plant proteins have larger extra-membrane domains than
are found in the bacterial MmpL3, but they have a similar TM domain
architecture (Malwal and Oldfield 2022).
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| Accession Number: | SYZ32255.1 |
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| Protein Name: | SYZ32255.1 Membrane transport protein MMPL-like [Propionibacterium australiense] |
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| Length: | 921 |
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| Molecular Weight: | |
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| Species: | Propionibacterium australiense [119981] |
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| Number of TMSs: | 12 |
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| Substrate |
lipid |
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1: MSSHLYRLGR AAFRRRRIVV LAWLLVLVAG FTLMGALSKG TDDTVRIPGA SSQSALDTLS
61: RVFPQVSGAS GMIVVVVPDG ASVRSQPERD AIGATVDQID ALGQVTTVAS PFSPLVSGAI
121: SADDTAAIIT IQFDGQRNEL TEQTLDSVRQ AADELQSRLG DGARVDVGGT AFDNVIPTIS
181: VVEAIGVVLA LVFLAVFLRN VLAAFVPIVM ALVGVAITES LVYAATGFMT IMSTTVLLSV
241: MIGLAVGIDY SLFIISRYRD NLAQGLEPEE AVARSIATAG TAVVFAGVTV IIALVGLFVA
301: RIPFLTIMGV ASAFGVGTAV CVAMTLLPAT LGFFGTRITP RPGRHRAGGD TFFGHWVRVV
361: TVRPLVTVVL VIAAVTVLAL PARGLRLSLP MESAAKPGSE VRTTYDTVSE KFGPGYNGPL
421: IVVVNVLDST DPVQAMTDLG EDLATVEGVQ RIAMATPNES GSYGIVQVIP TGSPDSAATA
481: ELVQALRAQG PAMAERYGLR DFAVTGITAV AVDVSAKLTH ALVPYGVFVV GLSLVLLVMV
541: FGSIAVPIKA TVGYLLSILA SFGVTTSIFV DGHLARLLGA DFTGSLICFL PIIVMGVLFG
601: LAMDYEVFLV SRTAEEYAHS GDPVQAIHEG FCKAAPVVTT AALIMLSVFA MFIPEGSSGI
661: IKPIATALTV GVFVDAFCVR MTLVPAVLRL LGHRAWTMPE RLARVLPRFD VEGASLTRQL
721: SLEGWPADGR EVVATKDMIV RDRDGAALNR PVDLDLRPGQ IAVLTGPEGS GKSELLLGLT
781: GRLTGFDGDA RVAGYLLPER NAAVRSRSVL TSGGRDVIGV LAEGLHRHVA LAAVDDADAV
841: IGTNRTAEVR DLIGRLAAAG GCVLLTGTSP DAVAHVLPDG TAPLRIAMEP PAPARFVPDD
901: PQRADGQSAP LSTILEEASR