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2.A.6.5.4
Sulfolipid, 2,3-diacyl-α, α'-D-trehalose-2'-sulfate (sulfatide precursor) exporter, MmpL8 (Domenech et al., 2004; Seeliger et al. 2012). Mutations associated with tuberculosis in mmpl8 as well as mmpl3 and mmpl9 have been isolated (Seeliger et al. 2012). Mutations associated with tuberculosis in mmpl8 as well as mmpl3 and mmpl9 have been isolated (Khan et al. 2022).

Accession Number:O07800
Protein Name:2,3-diacyl-Éø, Éø'-D-trehalose-2'-sulfate (sulfatide precursor) exporter, MmpL8
Length:1089
Molecular Weight:115998.00
Species:Mycobacterium tuberculosis [1773]
Number of TMSs:13
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

RefSeq: NP_218340.1    NP_338484.1   
Entrez Gene ID: 886145    922579   
KEGG: mtc:MT3931    mtu:Rv3823c   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0006869 P:lipid transport

References (7)

[1] “Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.”  Cole S.T.et.al.   9634230
[2] “Whole-genome comparison of Mycobacterium tuberculosis clinical and laboratory strains.”  Fleischmann R.D.et.al.   12218036
[3] “MmpL8 is required for sulfolipid-1 biosynthesis and Mycobacterium tuberculosis virulence.”  Converse S.E.et.al.   12724526
[4] “The role of MmpL8 in sulfatide biogenesis and virulence of Mycobacterium tuberculosis.”  Domenech P.et.al.   15001577
[5] “Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance.”  Domenech P.et.al.   15908378
[6] “The Mycobacterium tuberculosis PhoPR two-component system regulates genes essential for virulence and complex lipid biosynthesis.”  Walters S.B.et.al.   16573683
[7] “targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.”  Raman K.et.al.   19099550

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MCDVLMQPVR TPRPSTNLRS KPLRPTGDGG VFPRLGRLIV RRPWVVIAFW VALAGLLAPT 
61:	VPSLDAISQR HPVAILPSDA PVLVSTRQMT AAFREAGLQS VAVVVLSDAK GLGAADERSY 
121:	KELVDALRRD TRDVVMLQDF VTTPPLRELM TSKDNQAWIL PVGLPGDLGS TQSKQAYARV 
181:	ADIVEHQVAG STLTANLTGP AATVADLNLT GQRDRSRIEF AITILLLVIL LIIYGNPITM 
241:	VLPLITIGMS VVVAQRLVAI AGLAGLGIAN QSIIFMSGMM VGAGTDYAVF LISRYHDYLR 
301:	QGADSDQAVK KALTSIGKVI AASAATVAIT FLGMVFTQLG ILKTVGPMLG ISVAVVFFAA 
361:	VTLLPALMVL TGRRGWIAPR RDLTRRFWRS SGVHIVRRPK THLLASALVL VILAGCAGLA 
421:	RYNYDDRKTL PASVESSIGY AALDKHFPSN LIIPEYLFIQ SSTDLRTPKA LADLEQMVQR 
481:	VSQVPGVAMV RGITRPAGRS LEQARTSWQA GEVGSKLDEG SKQIAVHTGD IDKLAGGANL 
541:	MASKLGDVRA QVNRAISTVG GLIDALAYLQ DLLGGNRVLG ELEGAEKLIG SMRALGDTID 
601:	ADASFVANNT EWASPVLGAL DSSPMCTADP ACASARTELQ RLVTARDDGT LAKISELARQ 
661:	LQATRAVQTL AATVSGLRGA LATVIRAMGS LGMSSPGGVR SKINLVNKGV NDLADGSRQL 
721:	AEGVQLLVDQ VKKMGFGLGE ASAFLLAMKD TATTPAMAGF YIPPELLSYA TGESVKAETM 
781:	PSEYRDLLGG LNVDQLKKVA AAFISPDGHS IRYLIQTDLN PFSTAAMDQI DAITAAARGA 
841:	QPNTALADAK VSVVGLPVVL KDTRDYSDHD LRLIIAMTVC IVLLILIVLL RAIVAPLYLI 
901:	GSVIVSYLAA LGIGVIVFQF LLGQEMHWSI PGLTFVILVA VGADYNMLLI SRLREEAVLG 
961:	VRSGVIRTVA STGGVITAAG LIMAASMYGL VFASLGSVVQ GAFVLGTGLL LDTFLVRTVT 
1021:	VPAIAVLVGQ ANWWLPSSWR PATWWPLGRR RGRAQRTKRK PLLPKEEEEQ SPPDDDDLIG 
1081:	LWLHDGLRL