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2.A.6.6.2
Patched (Ptc) segmentation polarity protein.  Patched is known to be an important component of Hedgehog signaling in organisms from Drosophila to humans. It displays a typical RND folding pattern. Although Hedgehog appears to bind to Patched, it probably does not catalyze its import; thus, Patched  may function as a Hedgehog receptor (Nikaido 2018). The two extramembranous loops of Patched are thought to face the exterior, and possibly play roles in the binding of the signal protein. However, Patched may indeed function as a transporter, possibly of small molecules (Taipale et al. 2002).

Accession Number:P18502
Protein Name:PATC aka PTC aka CG2411
Length:1286
Molecular Weight:142831.00
Species:Drosophila melanogaster (Fruit fly) [7227]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Membrane1 / Multi-pass membrane protein2
Substrate Unknown

Cross database links:

eggNOG: inNOG05151
DIP: DIP-634N
RefSeq: NP_523661.2   
Entrez Gene ID: 35851   
Pfam: PF02460   
BioCyc: DMEL-XXX-02:DMEL-XXX-02-003463-MONOMER   
KEGG: dme:Dmel_CG2411   

Gene Ontology

GO:0030139 C:endocytic vesicle
GO:0005887 C:integral to plasma membrane
GO:0048471 C:perinuclear region of cytoplasm
GO:0008158 F:hedgehog receptor activity
GO:0030228 F:lipoprotein receptor activity
GO:0048099 P:anterior/posterior lineage restriction, ima...
GO:0007411 P:axon guidance
GO:0001746 P:Bolwig's organ morphogenesis
GO:0016311 P:dephosphorylation
GO:0035225 P:determination of genital disc primordium
GO:0007455 P:eye-antennal disc morphogenesis
GO:0042078 P:germ-line stem cell division
GO:0007476 P:imaginal disc-derived wing morphogenesis
GO:0055088 P:lipid homeostasis
GO:0045879 P:negative regulation of smoothened signaling...
GO:0030707 P:ovarian follicle cell development
GO:0007422 P:peripheral nervous system development
GO:0006508 P:proteolysis
GO:0007346 P:regulation of mitotic cell cycle
GO:0042306 P:regulation of protein import into nucleus
GO:0007367 P:segment polarity determination
GO:0007224 P:smoothened signaling pathway
GO:0048103 P:somatic stem cell division
GO:0048100 P:wing disc anterior/posterior pattern formation

References (4)

[1] “The Drosophila patched gene encodes a putative membrane protein required for segmental patterning.”  Hooper J.E.et.al.   2582494
[2] “A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched.”  Nakano Y.et.al.   2797178
[3] “The genome sequence of Drosophila melanogaster.”  Adams M.D.et.al.   10731132
[4] “Annotation of the Drosophila melanogaster euchromatic genome: a systematic review.”  Misra S.et.al.   12537572

External Searches:

  • Search: DB with
  • BLAST ExPASy (Swiss Institute of Bioinformatics (SIB) BLAST)
  • CDD Search (Conserved Domain Database)
  • Search COGs (Clusters of Orthologous Groups of proteins)
  • 2° Structure (Network Protein Sequence Analysis)

Analyze:

Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MDRDSLPRVP DTHGDVVDEK LFSDLYIRTS WVDAQVALDQ IDKGKARGSR TAIYLRSVFQ 
61:	SHLETLGSSV QKHAGKVLFV AILVLSTFCV GLKSAQIHSK VHQLWIQEGG RLEAELAYTQ 
121:	KTIGEDESAT HQLLIQTTHD PNASVLHPQA LLAHLEVLVK ATAVKVHLYD TEWGLRDMCN 
181:	MPSTPSFEGI YYIEQILRHL IPCSIITPLD CFWEGSQLLG PESAVVIPGL NQRLLWTTLN 
241:	PASVMQYMKQ KMSEEKISFD FETVEQYMKR AAIGSGYMEK PCLNPLNPNC PDTAPNKNST 
301:	QPPDVGAILS GGCYGYAAKH MHWPEELIVG GAKRNRSGHL RKAQALQSVV QLMTEKEMYD 
361:	QWQDNYKVHH LGWTQEKAAE VLNAWQRNFS REVEQLLRKQ SRIATNYDIY VFSSAALDDI 
421:	LAKFSHPSAL SIVIGVAVTV LYAFCTLLRW RDPVRGQSSV GVAGVLLMCF STAAGLGLSA 
481:	LLGIVFNAAS TQVVPFLALG LGVDHIFMLT AAYAESNRRE QTKLILKKVG PSILFSACST 
541:	AGSFFAAAFI PVPALKVFCL QAAIVMCSNL AAALLVFPAM ISLDLRRRTA GRADIFCCCF 
601:	PVWKEQPKVA PPVLPLNNNN GRGARHPKSC NNNRVPLPAQ NPLLEQRADI PGSSHSLASF 
661:	SLATFAFQHY TPFLMRSWVK FLTVMGFLAA LISSLYASTR LQDGLDIIDL VPKDSNEHKF 
721:	LDAQTRLFGF YSMYAVTQGN FEYPTQQQLL RDYHDSFVRV PHVIKNDNGG LPDFWLLLFS 
781:	EWLGNLQKIF DEEYRDGRLT KECWFPNASS DAILAYKLIV QTGHVDNPVD KELVLTNRLV 
841:	NSDGIINQRA FYNYLSAWAT NDVFAYGASQ GKLYPEPRQY FHQPNEYDLK IPKSLPLVYA 
901:	QMPFYLHGLT DTSQIKTLIG HIRDLSVKYE GFGLPNYPSG IPFIFWEQYM TLRSSLAMIL 
961:	ACVLLAALVL VSLLLLSVWA AVLVILSVLA SLAQIFGAMT LLGIKLSAIP AVILILSVGM 
1021:	MLCFNVLISL GFMTSVGNRQ RRVQLSMQMS LGPLVHGMLT SGVAVFMLST SPFEFVIRHF 
1081:	CWLLLVVLCV GACNSLLVFP ILLSMVGPEA ELVPLEHPDR ISTPSPLPVR SSKRSGKSYV 
1141:	VQGSRSSRGS CQKSHHHHHK DLNDPSLTTI TEEPQSWKSS NSSIQMPNDW TYQPREQRPA 
1201:	SYAAPPPAYH KAAAQQHHQH QGPPTTPPPP FPTAYPPELQ SIVVQPEVTV ETTHSDSNTT 
1261:	KVTATANIKV ELAMPGRAVR SYNFTS