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| Accession Number: | Q19127 |
| Protein Name: | Niemann-Pick C1 protein homolog 1 |
| Length: | 1383 |
| Molecular Weight: | 155457.00 |
| Species: | Caenorhabditis elegans [6239] |
| Number of TMSs: | 13 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | cholesterol |
Cross database links:
| Entrez Gene ID: | 180719 |
|---|---|
| Pfam: | PF02460 |
| KEGG: | cel:F02E8.6 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0008158
F:hedgehog receptor activity
GO:0042632
P:cholesterol homeostasis
GO:0030301
P:cholesterol transport
GO:0040024
P:dauer larval development
GO:0009792
P:embryo development ending in birth or egg hatching
GO:0040010
P:positive regulation of growth rate
GO:0046662
P:regulation of oviposition
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References (4)[1] “Genome sequence of the nematode C. elegans: a platform for investigating biology.” The C. elegans sequencing consortiumet.al. 9851916 [2] “A model for Niemann-Pick type C disease in the nematode Caenorhabditis elegans.” Sym M.et.al. 10801441 [3] “Murine model of Niemann-Pick C disease: mutation in a cholesterol homeostasis gene.” Loftus S.K.et.al. 9211850 [4] “Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis elegans and suggests an atypical translocation mechanism for integral membrane proteins.” Kaji H.et.al. 17761667
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MKQLLIFCLL FGSIFHHGDA GCIMRGLCQK HTENAYGPCV TNDTNVEPTA FDKTHPAYEK 61: MVEFCPHLLT GDNKLCCTPS QAEGLTKQIA QARHILGRCP SCFDNFAKLW CEFTCSPNQQ 121: DFVSISEMKP IEKKEGFTPE YQPAEAYVNT VEYRLSTDFA EGMFSSCKDV TFGGQPALRV 181: MCTSTPCTLT NWLEFIGTQN LDLNIPIHTK FLLYDPIKTP PSDRSTYMNV NFTGCDKSAR 241: VGWPACSTSE CNKEEYANLI DLDDGKTSGQ TCNVHGIACL NIFVMLAFIG SLAVLLCVGF 301: VFTSYDEDYT NLRQTQSGEE SPKRNRIKRT GAWIHNFMEN NARDIGMMAG RNPKSHFFIG 361: CAVLIFCLPG MIYHKESTNV VDMWSSPRSR ARQEEMVFNA NFGRPQRYQQ IMLLSHRDFQ 421: SSGKLYGPVF HKDIFEELFD ILNAIKNIST QDSDGRTITL DDVCYRPMGP GYDCLIMSPT 481: NYFQGNKEHL DMKSNKEETV SEDDDAFDYF SSEATTDEWM NHMAACIDQP MSQKTKSGLS 541: CMGTYGGPSA PNMVFGKNST NHQAANSIMM TILVTQRTEP EIQKAELWEK EFLKFCKEYR 601: EKSPKVIFSF MAERSITDEI ENDAKDEIVT VVIALAFLIG YVTFSLGRYF VCENQLWSIL 661: VHSRICLGML SVIINLLSSF CSWGIFSMFG IHPVKNALVV QFFVVTLLGV CRTFMVVKYY 721: AQQRVSMPYM SPDQCPEIVG MVMAGTMPAM FSSSLGCAFS FFIGGFTDLP AIRTFCLYAG 781: LAVLIDVVLH CTIFLALFVW DTQRELNGKP EFFFPYQIKD LLGAYLIGRQ RATDTFMTQF 841: FHFQVAPFLM HRMTRIITGI IFIASFITTV ILSSKISVGF DQSMAFTEKS YISTHFRYLD 901: KFFDVGPPVF FTVDGELDWH RPDVQNKFCT FPGCSDTSFG NIMNYAVGHT EQTYLSGEMY 961: NWIDNYLEWI SRKSPCCKVY VHDPNTFCST NRNKSALDDK ACRTCMDFDY VANSYPKSSI 1021: MYHRPSIEVF YRHLRHFLED TPNSECVFGG RASFKDAISF TSRGRIQASQ FMTFHKKLSI 1081: SNSSDFIKAM DTARMVSRRL ERSIDDTAHV FAYSKIFPFY EQYSTIMPIL TTQLFITVVG 1141: VFGIICVTLG IDVKGAACAV ICQVSNYFHI VAFMYIFNIP VNALSATNLV MSSGILIEFS 1201: VNVLKGYACS LRQRAKDRAE STVGSIGPII LSGPVVTMAG STMFLSGAHL QIITVYFFKL 1261: FLITIVSSAV HALIILPILL AFGGSRGHGS SETSTNDNDE QHDACVLSPT AESHISNVEE 1321: GILNRPSLLD ASHILDPLLK AEGGIDKAID IITIDRSYPS TPSSLPCTSR MPRAHIEPDL 1381: RSL