2.A.60.1.15
OAT family 1C1 protein, isoform 1, Oatp1c1; transports thyroid horomone and other organic anions (Westholm et al. 2010). (83% identical to 2.A.60.1.10). Primary and secondary thyroid hormone transporters have been reviewed (Kinne et al., 2011) and (Bernal et al. 2015). Together with MTC8 (TC# 2.A.1.13.10), OATP1C1 controls skeletal muscle regeneration (Mayerl et al. 2018). Thyroid hormone transporters MCT8 and OATP1C1 are expressed in projection neurons and interneurons of basal ganglia and motor thalamus in adult human brains (Wang et al. 2023). Assays have been developed to screen chemicals for their capacity to inhibit thyroid hormone transmembrane transporter proteins, OATP1C1 and OAT4 (Wagenaars et al. 2024). Tetrabromobisphenol A (TBBPA) was identified as an OATP1C1 inhibitor, more potent than any of the reference chemicals tested, and perfluorooctanesulfonic acid (PFOS), perfluoroctanic acid (PFOA), pentachlorophenol and quercetin are OATP1C1 inhibitors in a similar range of potency to the reference chemicals tested. Bromosulfophthalein, TBBPA, PFOA and PFOS were identified as potent OAT4 inhibitors (Wagenaars et al. 2024).