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2.A.60.1.18
Solute carrier organic anion transporter family, member 3A1, of 710 aas and 12 TMSs in a 3 + 3 + 3 + 3 TMS arrangement.  Transport of aromatic amino acids, l-tryptophan, l-tyrosine, and l-phenylalanine, by the organic anion transporting polypeptide (OATP) 3A1 has been demonstrated (Surrer et al. 2024).  OATP3A1 (gene symbol SLCO3A1, Uniprot: Q9UIG8) is ubiquitously expressed in human cells and highly expressed in many cancer tissues and cell lines (Surrer et al. 2024). Specifically, OATP3A1-mediated transport of l-tryptophan, l-tyrosine, and l-phenylalanine with 194.8 ± 28.7% (P < 0.05), 226.2 ± 18.7% (P < 0.001), and 235.2 ± 13.5% (P < 0.001), respectively, in OATP3A1-overexpressing cells compared to control cells. Furthermore, kinetic transport parameters (Km values) were determined (Trp = 61.5 ± 14.2 μm, Tyr = 220.8 ± 54.5 μm, Phe = 234.7 ± 20.6 μm).

Accession Number:Q9UIG8
Protein Name:Solute carrier organic anion transporter family member 3A1
Length:710
Molecular Weight:76553.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:12
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate organic anion

Cross database links:

Entrez Gene ID: 28232   
Pfam: PF07648    PF03137   
KEGG: hsa:28232    hsa:28232   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0043252 P:sodium-independent organic anion transport
GO:0055085 P:transmembrane transport

References (10)

[1] “Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.”  Tamai I.et.al.   10873595
[2] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[3] “Analysis of the DNA sequence and duplication history of human chromosome 15.”  Zody M.C.et.al.   16572171
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain.”  Huber R.D.et.al.   16971491
[6] “Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family.”  Tamai I.et.al.   10873595
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “Analysis of the DNA sequence and duplication history of human chromosome 15.”  Zody M.C.et.al.   16572171
[9] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[10] “Characterization of two splice variants of human organic anion transporting polypeptide 3A1 isolated from human brain.”  Huber R.D.et.al.   16971491

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FASTA formatted sequence 
1:	MQGKKPGGSS GGGRSGELQG DEAQRNKKKK KKVSCFSNIK IFLVSECALM LAQGTVGAYL 
61:	VSVLTTLERR FNLQSADVGV IASSFEIGNL ALILFVSYFG ARGHRPRLIG CGGIVMALGA 
121:	LLSALPEFLT HQYKYEAGEI RWGAEGRDVC AANGSGGDEG PDPDLICRNR TATNMMYLLL 
181:	IGAQVLLGIG ATPVQPLGVS YIDDHVRRKD SSLYIGILFT MLVFGPACGF ILGSFCTKIY 
241:	VDAVFIDTSN LDITPDDPRW IGAWWGGFLL CGALLFFSSL LMFGFPQSLP PHSEPAMESE 
301:	QAMLSEREYE RPKPSNGVLR HPLEPDSSAS CFQQLRVIPK VTKHLLSNPV FTCIILAACM 
361:	EIAVVAGFAA FLGKYLEQQF NLTTSSANQL LGMTAIPCAC LGIFLGGLLV KKLSLSALGA 
421:	IRMAMLVNLV STACYVSFLF LGCDTGPVAG VTVPYGNSTA PGSALDPYSP CNNNCECQTD 
481:	SFTPVCGADG ITYLSACFAG CNSTNLTGCA CLTTVPAENA TVVPGKCPSP GCQEAFLTFL 
541:	CVMCICSLIG AMAQTPSVII LIRTVSPELK SYALGVLFLL LRLLGFIPPP LIFGAGIDST 
601:	CLFWSTFCGE QGACVLYDNV VYRYLYVSIA IALKSFAFIL YTTTWQCLRK NYKRYIKNHE 
661:	GGLSTSEFFA STLTLDNLGR DPVPANQTHR TKFIYNLEDH EWCENMESVL