2.A.60.1.2
Prostaglandin transporter, Pgt or PGT (SLC21A2) (substrates: eicosanoids including several prostaglandins and thromboxanes). Prostaglandins (PGs) transported include PGE2 PGF and PGH2 (Chi and Schuster, 2010). Pgt is an important mediator of ovulation, and its inhibitors are
potential candidates for nonhormonal contraception (Yerushalmi et al. 2016). PGT is involved in the
clearance of PGE2 from the brain during the recovery phase of LPS-induced acute-phase responses (Hosotani et al. 2015).
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| Accession Number: | Q00910 |
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| Protein Name: | PGT aka Slc21a2 |
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| Length: | 643 |
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| Molecular Weight: | 70569.00 |
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| Species: | Rattus norvegicus (Rat) [10116] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
prostaglandin, icosanoid, thromboxane |
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| RefSeq: |
NP_073158.1
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| Entrez Gene ID: |
24546
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| Pfam: |
PF07648
PF03137
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| KEGG: |
rno:24546
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[1] “Molecular cloning of matrin F/G: a DNA binding protein of the nuclear matrix that contains putative zinc finger motifs.” Hakes D.J. et.al. 2068100
[2] “Identification and characterization of a prostaglandin transporter.” Kanai N. et.al. 7754369
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1: MGLLLKPGAR QGSGTSSVPD RRCPRSVFSN IKVFVLCHGL LQLCQLLYSA YFKSSLTTIE
61: KRFGLSSSSS GLISSLNEIS NATLIIFISY FGSRVNRPRM IGIGGLLLAA GAFVLTLPHF
121: LSEPYQYTST TDGNRSSFQT DLCQKHFGAL PPSKCHSTVP DTHKETSSLW GLMVVAQLLA
181: GIGTVPIQPF GISYVDDFAE PTNSPLYISI LFAIAVFGPA FGYLLGSVML RIFVDYGRVD
241: TATVNLSPGD PRWIGAWWLG LLISSGFLIV TSLPFFFFPR AMSRGAERSV TAEETMQTEE
301: DKSRGSLMDF IKRFPRIFLR LLMNPLFMLV VLSQCTFSSV IAGLSTFLNK FLEKQYGATA
361: AYANFLIGAV NLPAAALGML FGGILMKRFV FPLQTIPRVA ATIITISMIL CVPLFFMGCS
421: TSAVAEVYPP STSSSIHPQQ PPACRRDCSC PDSFFHPVCG DNGVEYVSPC HAGCSSTNTS
481: SEASKEPIYL NCSCVSGGSA SQDRLMPHVL RALLLPSIFL ISFAALIACI SHNPLYMMVL
541: RVVNQDEKSF AIGVQFLLMR LLAWLPAPSL YGLLIDSSCV RWNYLCSGRR GACAYYDNDA
601: LRNRYLGLQM VYKALGTLLL FFISWRMKKN REYSLQENTS GLI