2.A.60.1.29
LST-3TM12 (LST3; SLCO1B7 is a product of splicing of SLCO1B3 and SLCO1B7, and encodes a protein with 640 aas and 12 TMSs. LST-3TM12 mRNA was verified by polymerase chain reaction showing liver enriched expression (Malagnino et al. 2017). LST-3TM12 is expressed in the PM and ER of hepatocytes and is associated with enhanced cellular accumulation of dehydroepiandrosterone sulfate (Vmax 300 pmol/mg/min; Km 34 µM) and estradiol 17-beta-glucuronide (Vmax 30 µmol/ mg/min; Km 33 µM) (Malagnino et al. 2017). Sreedharan et al. 2011 examined the tissue distribution of this porter.
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| Accession Number: | G3V0H7 |
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| Protein Name: | Putative solute carrier organic anion transporter family member 1B7 |
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| Length: | 640 |
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| Molecular Weight: | 71247.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 11 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
dehydroepiandrosterone sulfate |
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1: MKISTTQIER RFEISSSLVG LIDGSFEIGN LFVIVFVSYF GSKLHRPKLI GIGCFLMGTG
61: SILMALPHFF MGYYRYSKET NIDPSENSTS NLPNCLINQM LSLNRTPSEI IERGCVKESG
121: SHMWIYVFMG NMLRGIGETP IVPLGISYID DFAKEGHSSL YLGTVNVMGM TGLVFAFMLG
181: SLFAKMYVDI GYVDLSTIRI TPKDSRWVGA WWLGFLVSGI VSIISSIPFF FLPLNPNKPQ
241: KERKVSLFLH VLKTNDKRNQ IANLTNRRKY ITKNVTGFFQ SLKSILTNPL YVIFVIFTLL
301: HMSSYIASLT YIIKMVEQQY GWSASKTNFL LGVLALPAVA IGMFSGGYII KKFKLSLVGL
361: AKLAFCSATV HLLSQVLYFF LICESKSVAG LTLTYDGNSP VRSHVDVPLS YCNSECNCDE
421: SQWEPVCGNN GITYLSPCLA GCKSSSGNKE PIVFYNCSCV EVIGLQNKNY SAHLGECPRD
481: DACTRKSYVY FVIQVLDAFL CAVGLTSYSV LVIRIVQPEL KALAIGFHSM IMRSLGGILV
541: PIYFGALIDT TCMKWSTNSC GARGACRIYN STYLGRAFFG LKVALIFPVL VLLTVFIFVV
601: RKKSHGKDTK VLENERQVMD EANLEFLNDS EHFVPSAEEQ