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| Accession Number: | O88397 |
| Protein Name: | OAT3 aka SLC21A7 aka OATP3 |
| Length: | 670 |
| Molecular Weight: | 74577.00 |
| Species: | Rattus norvegicus (Rat) [10116] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Membrane1 / Multi-pass membrane protein2 |
| Substrate | cholate, 3,3',5-triiodo-L-thyronine, ciprofloxacin, taurocholic acid, icosanoid, thyroxine |
Cross database links:
| RefSeq: | NP_110465.1 |
|---|---|
| Entrez Gene ID: | 80900 |
| Pfam: | PF07648 PF03137 |
| KEGG: | rno:80900 |
Gene Ontology
GO:0031526
C:brush border membrane
GO:0005887
C:integral to plasma membrane
GO:0005624
C:membrane fraction
GO:0015125
F:bile acid transmembrane transporter activity
GO:0008514
F:organic anion transmembrane transporter act...
GO:0015349
F:thyroid hormone transmembrane transporter a...
GO:0015721
P:bile acid and bile salt transport
GO:0050892
P:intestinal absorption
GO:0031100
P:organ regeneration
GO:0015711
P:organic anion transport
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References (2)[1] “Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2.” Abe T.et.al. 9712861 [2] “Expression, transport properties, and chromosomal location of organic anion transporter subtype 3.” Walters H.C.et.al. 11093941
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MGETEKRVAT HEVRCFSKIK MFLLALTWAY VSKSLSGIYM NTMLTQIERQ FDIPTSIVGF 61: INGSFEIGNL LLIIFVSYFG TKLHRPIMIG VGCVIMGLGC FLMSLPHFLM GRYEYETTIS 121: PTSNLSSNSF LCMENRSQTL KPTQDPAECI KEMKSLMWIY VLVGNIIRGI GETPIMPLGI 181: SYIEDFAKSE NSPLYIGILE TGKVFGPIVG LLLGSFCASI YVDTGSVNTD DLTITPTDTR 241: WVGAWWIGFL ICAGVNILSS IPFFFFPKTL PKEGLQDDVD GTNNDKEEKH REKAKEENRG 301: ITKDFLPFMK SLSCNPIYML LILTSVLQIN AFINMFTFLP KYLEQQYGKS TAEVVLLIGV 361: YNLPPICIGY LLIGFIMKKF KITVKKAAYM AFCLSLFEYL LYFLHFMITC DNFPVAGLTA 421: SYEGVHHPLY VENKVLADCN RGCSCSTNSW DPVCGDNGLA YMSACLAGCK KSVGTGTNMV 481: FQNCSCIRSS GNSSAVLGLC KKGPECANKL QYFLIMSVIG SFIYSITAIP GYMVLLRCIK 541: PEEKSLGIGL HAFCTRVFAG IPAPIYFGAL IDRTCLHWGT LKCGEPGACR MYNINNFRRI 601: YLVLPAALRG SSYLPALFIL ILMRKFQFPG EIDSSETELA EMKITVKKSE CTDVHGSPQV 661: ENDGELKTRL