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2.A.60.1.8 Oat4 (SLC21A10). Transports bile salts, eicosanoids, urate, hormones and their conjugates, toxins and other anions. Functions in urate reabsorption across the renal appical membrane (Prestin et al. 2014).
Accession Number:	Q9QZX8
Protein Name:	OAT4 aka SLC21A10
Length:	652
Molecular Weight:	72767.00
Species:	Rattus norvegicus (Rat) [10116]
Number of TMSs:	10
Location¹ / Topology² / Orientation³:	Basolateral cell membrane¹ / Multi-pass membrane protein²
Substrate	anion, icosanoid, 7,9-dihydro-1H-purine-2,6,8(3H)-trione, hormone, bile acid, toxin

RefSeq:	NP_113838.1
Entrez Gene ID:	58978
Pfam:	PF07648 PF03137
KEGG:	rno:58978
Gene Ontology GO:0016323 C:basolateral plasma membrane GO:0016021 C:integral to membrane GO:0015125 F:bile acid transmembrane transporter activity GO:0015238 F:drug transmembrane transporter activity GO:0015198 F:oligopeptide transporter activity GO:0008514 F:organic anion transmembrane transporter act... GO:0015721 P:bile acid and bile salt transport GO:0015893 P:drug transport GO:0006811 P:ion transport GO:0001889 P:liver development GO:0006857 P:oligopeptide transport GO:0046677 P:response to antibiotic GO:0051384 P:response to glucocorticoid stimulus GO:0033993 P:response to lipid GO:0032496 P:response to lipopolysaccharide GO:0043434 P:response to peptide hormone stimulus
References (5) [1] “Molecular characterization and functional regulation of a novel rat liver-specific organic anion transporter rlst-1.” Kakyo M.et.al. 10500057 [2] “Cloning of the full-length coding sequence of rat liver-specific organic anion transporter-1 (rlst-1) and a splice variant and partial characterization of the rat lst-1 gene.” Choudhuri S.et.al. 10903899 [3] “Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver.” Cattori V.et.al. 10838093 [4] “Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3.” Cattori V.et.al. 11713643 [5] “Phosphoproteomic analysis of rat liver by high capacity IMAC and LC-MS/MS.” Moser K.et.al. 16396499

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

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FASTA formatted sequence

1:	MDHTQQSRKA AEAQPSRSKQ TRFCDGFKLF LAALSFSYIC KALGGVVMKS SITQIERRFD 
61:	IPSSISGLID GGFEIGNLLV IVFVSYFGSK LHRPKLIGIG CFIMGIGSIL TALPHFFMGY 
121:	YKYAKENDIG SLGNSTLTCF INQMTSPTGP SPEIVEKGCE KGLKSHMWIY VLMGNMLRGI 
181:	GETPIVPLGI SYLDDFAKEG HTSMHLGTLH TIAMIGPILG FIMSSVFAKI YVDVGYVDLN 
241:	SVRITPNDAR WVGAWWLSFI VNGLLCITSS IPFFFLPKIP KRSQEERKNS VSLHAPKTDE 
301:	EKKHMTNLTK QEEQDPSNMT GFLRSLRSIL TNEIYVIFLI LTLLQVSGFI GSFTYLFKFI 
361:	EQQFGRTASQ ANFLLGIITI PTMATAMFLG GYIVKKFKLT SVGIAKMNPV DSHIDVPLSY 
421:	CNSDCSCDKN QWEPICGENG VTYISPCLAG CKSFRGDKKP NNTEFYDCSC ISNSGNNSAH 
481:	LGECPRYKCK TNYYFYIILQ VTVSFFTAMG SPSLILILMK SVQPELKSLA MGFHSLIIRA 
541:	LGGILAPIYY GAFIDRTCIK WSVTSCGKRG ACRLYNSRLF GFSYLGLNLA LKTPPLFLYV 
601:	VLIYFTKRKY KRNDNKTLEN GRQFTDEGNP DSVNKNGYYC VPYDEQSNET PL

2.A.60.1.8
Oat4 (SLC21A10). Transports bile salts, eicosanoids, urate, hormones and their conjugates, toxins and other anions. Functions in urate reabsorption across the renal appical membrane (Prestin et al. 2014).

Cross database links:

Gene Ontology

References (5)

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2.A.60.1.8Oat4 (SLC21A10). Transports bile salts, eicosanoids, urate, hormones and their conjugates, toxins and other anions. Functions in urate reabsorption across the renal appical membrane (Prestin et al. 2014).

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

2.A.60.1.8
Oat4 (SLC21A10). Transports bile salts, eicosanoids, urate, hormones and their conjugates, toxins and other anions. Functions in urate reabsorption across the renal appical membrane (Prestin et al. 2014).