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2.A.61.1.1 Anaerobic C₄-dicarboxylate transporter (DcuC) which functions to transport dicarboxylates during glucose fermentation (Zientz et al. 1999). Also facilitates succinate efflux (Chen et al. 2014).
Accession Number:	P0ABP3
Protein Name:	Anaerobic C4-dicarboxylate transporter DcuC aka B0621
Length:	461
Molecular Weight:	48412.00
Species:	Escherichia coli [83333]
Number of TMSs:	14
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate

RefSeq:	AP_001268.1 AP_001270.1 NP_415154.1
Entrez Gene ID:	945000
Pfam:	PF03606
BioCyc:	EcoCyc:DCUC-MONOMER ECOL168927:B0621-MONOMER
KEGG:	eco:b0621
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0015556 F:C4-dicarboxylate transmembrane transporter ... GO:0015740 P:C4-dicarboxylate transport
References (6) [1] “Identification of a third secondary carrier (DcuC) for anaerobic C4-dicarboxylate transport in Escherichia coli: roles of the three Dcu carriers in uptake and exchange.” Zientz E.et.al. 8955408 [2] “A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map.” Oshima T.et.al. 8905232 [3] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [4] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [5] “Functioning of DcuC as the C4-dicarboxylate carrier during glucose fermentation by Escherichia coli.” Zientz E.et.al. 10368146 [6] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MLTFIELLIG VVVIVGVARY IIKGYSATGV LFVGGLLLLI ISAIMGHKVL PSSQASTGYS 
61:	ATDIVEYVKI LLMSRGGDLG MMIMMLCGFA AYMTHIGAND MVVKLASKPL QYINSPYLLM 
121:	IAAYFVACLM SLAVSSATGL GVLLMATLFP VMVNVGISRG AAAAICASPA AIILAPTSGD 
181:	VVLAAQASEM SLIDFAFKTT LPISIAAIIG MAIAHFFWQR YLDKKEHISH EMLDVSEITT 
241:	TAPAFYAILP FTPIIGVLIF DGKWGPQLHI ITILVICMLI ASILEFLRSF NTQKVFSGLE 
301:	VAYRGMADAF ANVVMLLVAA GVFAQGLSTI GFIQSLISIA TSFGSASIIL MLVLVILTML 
361:	AAVTTGSGNA PFYAFVEMIP KLAHSSGINP AYLTIPMLQA SNLGRTLSPV SGVVVAVAGM 
421:	AKISPFEVVK RTSVPVLVGL VIVIVATELM VPGTAAAVTG K

2.A.61.1.1
Anaerobic C₄-dicarboxylate transporter (DcuC) which functions to transport dicarboxylates during glucose fermentation (Zientz et al. 1999). Also facilitates succinate efflux (Chen et al. 2014).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

2.A.61.1.1Anaerobic C4-dicarboxylate transporter (DcuC) which functions to transport dicarboxylates during glucose fermentation (Zientz et al. 1999). Also facilitates succinate efflux (Chen et al. 2014).

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

2.A.61.1.1
Anaerobic C₄-dicarboxylate transporter (DcuC) which functions to transport dicarboxylates during glucose fermentation (Zientz et al. 1999). Also facilitates succinate efflux (Chen et al. 2014).