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Accession Number: | Q8K0H1 |
Protein Name: | Multidrug and toxin extrusion protein 1 |
Length: | 567 |
Molecular Weight: | 61642.00 |
Species: | Mus musculus (Mouse) [10090] |
Number of TMSs: | 13 |
Location1 / Topology2 / Orientation3: | Cell membrane1 / Multi-pass membrane protein2 |
Substrate | triethylamine, drug |
Cross database links:
RefSeq: | NP_080459.2 |
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Entrez Gene ID: | 67473 |
Pfam: | PF01554 |
KEGG: | mmu:67473 |
Gene Ontology
GO:0016021
C:integral to membrane
GO:0005886
C:plasma membrane
GO:0015297
F:antiporter activity
GO:0015238
F:drug transmembrane transporter activity
GO:0006855
P:drug transmembrane transport
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References (6)[1] “The transcriptional landscape of the mammalian genome.” Carninci P.et.al. 16141072 [2] “Lineage-specific biology revealed by a finished genome assembly of the mouse.” Church D.M.et.al. 19468303 [3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).” The MGC Project Teamet.al. 15489334 [4] “A human transporter protein that mediates the final excretion step for toxic organic cations.” Otsuka M.et.al. 16330770 [5] “Wide variety of locations for rodent MATE1, a transporter protein that mediates the final excretion step for toxic organic cations.” Hiasa M.et.al. 16641166 [6] “Functional characterization of testis-specific rodent multidrug and toxic compound extrusion 2, a class III MATE-type polyspecific H+/organic cation exporter.” Hiasa M.et.al. 17715386
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External Searches:
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Analyze:
Predict TMSs (Predict number of transmembrane segments) | ||||
FASTA formatted sequence |
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1: MERTEESAPG PGGADAASER RGLRCLLLPG FLEELRALLV LAGPAFLAQL MMFLISFISS 61: VFCGHLGKLE LDAVTLAIAV INVTGISVGH GLSSACDTLI SQTYGSQNLK HVGVILQRGT 121: LILLLCCFPC WALFINTEQI LLLFRQDPDV SRLTQTYVMI FIPALPAAFL YTLQVKYLLN 181: QGIVLPQIMT GIAANLVNAL ANYVFLYHLH LGVMGSALAN TISQFALAIF LFLYILWRRL 241: HQATWGGWSW ECLQDWASFL RLAIPSMLML CIEWWAYEVG SFLSGILGMV ELGAQSITYE 301: LAIIVYMIPS GFSVAANVRV GNALGAGNID QAKKSSAISL IVTELFAVTF CVLLLGCKDL 361: VGYIFTTDRD IVALVAQVIP IYAVSHLFEG LACTCGGILR GTGNQKVGAI VNAIGYYVIG 421: LPIGIALMFA AKLGVIGLWS GIIICTTCQT TCFLAFIARL NWKRACQQAQ VHANLKVNVA 481: LNSAVSHEPA HPVCPESHGE IMMTDLEKKD ETQLDQPMNQ QQALPIRPKD SNKLSGKQLA 541: LRRGLLLLGV VLVLVGGILV RVYIRIE