2.A.66.1.41
Na+-coupled multidrug efflux pump, PdrM (Hashimoto et al. 2013). Confers resistance to several antibacterial agents including norfloxacin, acriflavine, and 4',6-diamidino-2-phenylindole (DAPI).
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| Accession Number: | Q8DPQ6 |
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| Protein Name: | Probable multidrug resistance protein NorM |
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| Length: | 453 |
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| Molecular Weight: | 50061.00 |
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| Species: | Streptococcus pneumoniae (strain ATCC BAA-255 / R6) [171101] |
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| Number of TMSs: | 12 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
sodium(1+), norfloxacin, 3,6-diamino-10-methylacridinium chloride, nifedipine |
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1: MYKTKCLREK LVLFLKIFFP ILIYQFANYS ASFVDTAMTG QYNTMDLAGV SMATSIWNPF
61: FTFLTGIVSA LVPIIGHHLG RGKKEEVASD FYQFIYLALG LSVVLLGMVL FLAPTILNHI
121: GLEAAVAAVA VRYLWFLSIG IIPLLLFSVI RSLLDSLGLT KLSMYLMLLL LPLNSGFNYL
181: LIYGAFGVPE LGGAGAGLGT SLAYWVLLGI SVLVLFKQEK LKALHLEKRI LLNMDKIKEG
241: VRLGLPIGGT VFAEVAVFSV VGLIMAKFSS LIIASHQSAM NFSSLMYAFP MSISSAMAIV
301: VSYEVGAKRF DDAKTYIGLG RWTALIFAAF TLTFLYIFRG NVASLYGNDP KFIDLTARFL
361: TYSLFFQLAD TFAAPLQGIL RGYKDTVIPF YLGLLGYWGV AIPVATLFDS LTDFGAYSYW
421: IGLIISLIVS GALYRWRLTV IMKRFESLAK SKR