2.A.7.10.5
ER/Golgi UDP-N-acetylglucosamine transporter, Yea4 of 342 aas. Required for chitin biosynthesis (Roy et al. 2000). Extracellular UDP-sugars promote cellular responses by interacting with widely distributed P2Y(14) receptors, and the ER/Golgi lumen constitutes a source of extracellular
UDP-sugars (Sesma et al. 2009). Yea4 therefore plays a critical role in nucleotide
sugar-promoted cell signaling.
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| Accession Number: | P40004 |
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| Protein Name: | UDP-N-acetylglucosamine transporter YEA4 |
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| Length: | 342 |
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| Molecular Weight: | 39266.00 |
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| Species: | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [559292] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Endoplasmic reticulum1 |
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| Substrate |
UDP-N-acetyl-alpha-D-glucosamine |
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1: MWNSLKAFAL VFGGCCSNVI TFETLMSNET GSINNLITFC QFLFVTCQGL PEFLDVHQPF
61: PYFKPLKTPL HVYVITVVLF YISSTTNNNV FKYNISIPIH IVFRCFGTVI TMFTCWLLNG
121: RKYTKIQILS TLFLTIGAII ASLFKDADFR YQDLKLQAWK IGSDQSVDLT FIFGICILVL
181: SSFTSSLLSA YNERTYQKYG KHWKENIFYS HFLSLPLFLF SRKQLIHEYR VMRKSERILC
241: SNFGGKILVP REETLLLFNV LTQYFCVKGV NILASKTNAL TLSITLLVRK FISLLLSVRL
301: FDNNLSYTGY IGVYLVFFGA FIYSLGSIHP RQNDKGAIKK SK