2.A.7.14.6
Tobacco nicotine uptake permease 1, NUP1, of 353 aas and 10 TMSs. NUP1 transports tobacco alkaloids such as nicotine, but also efficiently takes up
pyridoxamine, pyridoxine and anatabine. The naturally
occurring (S)-isomer of nicotine was preferentially transported over the
(R)-isomer. NUP1, similar to PUP1 of A. thaiana,
transported various compounds containing a pyridine ring, but the
two transporters had distinct substrate preferences (Kato et al. 2015).
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| Accession Number: | G8A929 |
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| Protein Name: | Nicotine uptake permease 1 |
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| Length: | 353 |
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| Molecular Weight: | 38831.00 |
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| Species: | Nicotiana tabacum (Common tobacco) [4097] |
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| Number of TMSs: | 10 |
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| Substrate |
(S)-nicotine, pyridoxine, pyridoxamine, 7H-purine, Anatabine |
|---|
1: MEHPGLSTNM RRILLLISCL ILAVGICGGP LMMRLYYVEG GSRIWLSSWL QTGGWPLTLI
61: PLAILYYYRR KTEGSNAKFY LMTPRIFIAS FVIGVATGLD DFLYSWGGSK LPVSTSSLLL
121: AAQLAFTAVG AFFIVKLKLS PFSINAVVLL TVGAVLLGIR SNGDRPEGVT SKEYIIGFMM
181: TLLAAALYGV ILPCIELIYM KAKQAITSTL VLEIQMIMSF AATAFCTVGM IANKDFQAMS
241: REAKQFNVGE ARYYTVIVCT AAIWQCFFVG IIGVIYCSSS LMSGVMIAVL LPVTEVLAVI
301: FFKENFSGEK GLALFLSLWG FVSYFYGEFR QTKKQKNTSP EAEMTITTHT ESV