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2.A.7.16.1
The GDP-fucose transporter (GFT) (defective in human leukocyte adhesion disease II) (SLC35C1) (Zhang et al. 2012).  SLC35A1 and SLC35C1, have been related to congenital disorder of glycosylation II (CDG II) (Song 2013). Triclosan activates c-Jun/miR-218-1-3p/SLC35C1 signaling to regulate the cell viability, migration, invasion and inflammatory response of trophoblast cells (Huo et al. 2022). Elevated global fucosylation characterizes human intrahepatic cholangiocarcinoma, contributing to cell growth and migration via the upregulation of the NOTCH and EGFR/NF-kB pathways (Ament et al. 2023). SLC35C1 knockdown significantly inhibited the proliferation, migration and invasive ability of glioma cells, while SLC35C1 overexpression promoted proliferation, migration, invasion and colony formation of glioma cells (Xie et al. 2023).   

Accession Number:Q96A29
Protein Name:GFT aka FUCT1
Length:364
Molecular Weight:39809.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Golgi apparatus membrane1 / Multi-pass membrane protein2
Substrate GDP-fucose

Cross database links:

RefSeq: NP_001138737.1    NP_001138738.1    NP_060859.4   
Entrez Gene ID: 55343   
Pfam: PF00892    PF03151   
OMIM: 266265  phenotype
605881  gene
KEGG: hsa:55343    hsa:55343   

Gene Ontology

GO:0000139 C:Golgi membrane
GO:0016021 C:integral to membrane
GO:0008643 P:carbohydrate transport
GO:0030259 P:lipid glycosylation
GO:0055085 P:transmembrane transport

References (8)

[1] “The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter.”  Luehn K.et.al.   11326279
[2] “Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency.”  Luebke T.et.al.   11326280
[3] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[4] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334
[5] “The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter.”  Luehn K.et.al.   11326279
[6] “Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency.”  Luebke T.et.al.   11326280
[7] “Complete sequencing and characterization of 21,243 full-length human cDNAs.”  Ota T.et.al.   14702039
[8] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MNRAPLKRSR ILHMALTGAS DPSAEAEANG EKPFLLRALQ IALVVSLYWV TSISMVFLNK 
61:	YLLDSPSLRL DTPIFVTFYQ CLVTTLLCKG LSALAACCPG AVDFPSLRLD LRVARSVLPL 
121:	SVVFIGMITF NNLCLKYVGV AFYNVGRSLT TVFNVLLSYL LLKQTTSFYA LLTCGIIIGG 
181:	FWLGVDQEGA EGTLSWLGTV FGVLASLCVS LNAIYTTKVL PAVDGSIWRL TFYNNVNACI 
241:	LFLPLLLLLG ELQALRDFAQ LGSAHFWGMM TLGGLFGFAI GYVTGLQIKF TSPLTHNVSG 
301:	TAKACAQTVL AVLYYEETKS FLWWTSNMMV LGGSSAYTWV RGWEMKKTPE EPSPKDSEKS 
361:	AMGV