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|---|---|
| Accession Number: | Q9GSB0 |
| Protein Name: | Crt homologue 1 |
| Length: | 473 |
| Molecular Weight: | 51809.00 |
| Species: | Dictyostelium discoideum (Slime mold) [44689] |
| Number of TMSs: | 12 |
| Location1 / Topology2 / Orientation3: | Cytoplasmic vesicle membrane1 / Multi-pass membrane protein2 |
| Substrate | chloroquine |
Cross database links:
| Entrez Gene ID: | 8620828 |
|---|---|
| Pfam: | PF08627 PF03151 |
| KEGG: | ddi:DDB_G027694 |
Gene Ontology
GO:0030659
C:cytoplasmic vesicle membrane
GO:0016021
C:integral to membrane
GO:0012506
C:vesicle membrane
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References (5)[1] “Evidence for different mechanisms of chloroquine resistance in 2 Plasmodium species that cause human malaria.” Nomura T.et.al. 11343215 [2] “Sequence and analysis of chromosome 2 of Dictyostelium discoideum.” Gloeckner G.et.al. 12097910 [3] “The genome of the social amoeba Dictyostelium discoideum.” Eichinger L.et.al. 15875012 [4] “Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT.” Naude B.et.al. 15883156 [5] “Expression and function of pvcrt-o, a Plasmodium vivax ortholog of pfcrt, in Plasmodium falciparum and Dictyostelium discoideum.” Sa J.M.et.al. 16987557
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External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MTNNDKEKQP LLSSINNEDD NGATINIVEP VPWYSNIPQK IKNSMSKETI TILIYVVLYV 61: TSGVINSVLL KKVMNKFTNY AFFLSQLTNF GYVPIFGAVT AYKIFFTKDI PQETRDFPTR 121: KFAIMGALDA ITGFFVVIGG VSTSGPLQQL LNQAIIPFTM IASFIFLKER YSLIQLGGAL 181: VIIGGVVTSL IPSLLGGSSG GNKPFWNFFY LLSVIPGALS NVYKDIGFQA VADMDVWYLQ 241: YWDSLYQSIF GLFLFPVNNW LPPPATVKFE QILPFMKEGA ECLAGINSII PSYINGTSSF 301: TATSCTYAPD ATITCDDCHN AWIVIILYMT INIIYNIFIL LVLKHAGATV YSIANTLRLP 361: LTNIVFSIHF IMGSAVSPFS GLSVAGLVII LVGLGGYRVG SMIKQKKAAA AGGAIKVIPS 421: YGPAGMDNII PVQKEYIEPK SQAHLRNQFF GKLGINVPEA RYRAANNNNY GDA