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2.A.72.1.1 Low affinity K⁺ uptake permease, KUP or TrkD. It has 12 established TMSs with four transmembrane acidic residues important for K+ uptake (Sato et al. 2014).
Accession Number:	P63183
Protein Name:	Low affinity potassium transport system protein KUP aka TRKD aka B3747
Length:	622
Molecular Weight:	69294.00
Species:	Escherichia coli [83333]
Number of TMSs:	13
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	potassium(1+)

RefSeq:	AP_004040.1 YP_026244.1
Entrez Gene ID:	948255
Pfam:	PF02705
BioCyc:	EcoCyc:KUP-MONOMER
KEGG:	ecj:JW5609 eco:b3747
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0015079 F:potassium ion transmembrane transporter act... GO:0015293 F:symporter activity GO:0006813 P:potassium ion transport
References (10) [1] “Nucleotide sequence and 3'-end deletion studies indicate that the K(+)-uptake protein kup from Escherichia coli is composed of a hydrophobic core linked to a large and partially essential hydrophilic C-terminus.” Schleyer M.et.al. 8226635 [2] “DNA sequence and analysis of 136 kilobases of the Escherichia coli genome: organizational symmetry around the origin of replication.” Burland V.D.et.al. 7686882 [3] “Analysis of the Escherichia coli genome. IV. DNA sequence of the region from 89.2 to 92.8 minutes.” Blattner F.R.et.al. 8265357 [4] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [5] “Escherichia coli K-12: a cooperatively developed annotation snapshot -- 2005.” Riley M.et.al. 16397293 [6] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [7] “Specific cesium transport via the Escherichia coli Kup (TrkD) K+ uptake system.” Bossemeyer D.et.al. 2649491 [8] “Kup is the major K+ uptake system in Escherichia coli upon hyper-osmotic stress at a low pH.” Trchounian A.et.al. 10214935 [9] “K+ influx by Kup in Escherichia coli is accompanied by a decrease in H+ efflux.” Zakharyan E.et.al. 11682179 [10] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996

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FASTA formatted sequence

1:	MSTDNKQSLP AITLAAIGVV YGDIGTSPLY TLRECLSGQF GFGVERDAVF GFLSLIFWLL 
61:	IFVVSIKYLT FVMRADNAGE GGILTLMSLA GRNTSARTTS MLVIMGLIGG SFFYGEVVIT 
121:	PAISVMSAIE GLEIVAPQLD TWIVPLSIIV LTLLFMIQKH GTAMVGKLFA PIMLTWFLIL 
181:	AGLGLRSIIA NPEVLHALNP MWAVHFFLEY KTVSFIALGA VVLSITGVEA LYADMGHFGK 
241:	FPIRLAWFTV VLPSLTLNYF GQGALLLKNP EAIKNPFFLL APDWALIPLL IIAALATVIA 
301:	SQAVISGVFS LTRQAVRLGY LSPMRIIHTS EMESGQIYIP FVNWMLYVAV VIVIVSFEHS 
361:	SNLAAAYGIA VTGTMVLTSI LSTTVARQNW HWNKYFVALI LIAFLCVDIP LFTANLDKLL 
421:	SGGWLPLSLG TVMFIVMTTW KSERFRLLRR MHEHGNSLEA MIASLEKSPP VRVPGTAVYM 
481:	SRAINVIPFA LMHNLKHNKV LHERVILLTL RTEDAPYVHN VRRVQIEQLS PTFWRVVASY 
541:	GWRETPNVEE VFHRCGLEGL SCRMMETSFF MSHESLILGK RPWYLRLRGK LYLLLQRNAL 
601:	RAPDQFEIPP NRVIELGTQV EI

2.A.72.1.1
Low affinity K⁺ uptake permease, KUP or TrkD. It has 12 established TMSs with four transmembrane acidic residues important for K+ uptake (Sato et al. 2014).

Cross database links:

Gene Ontology

References (10)

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2.A.72.1.1Low affinity K+ uptake permease, KUP or TrkD. It has 12 established TMSs with four transmembrane acidic residues important for K+ uptake (Sato et al. 2014).

Cross database links:

Gene Ontology

References (10)

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Analyze:

2.A.72.1.1
Low affinity K⁺ uptake permease, KUP or TrkD. It has 12 established TMSs with four transmembrane acidic residues important for K+ uptake (Sato et al. 2014).