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2.A.74.1.4
Lysosomal-associated transmembrane protein 5 (Lysosomal-associated multitransmembrane protein 5) (Retinoic acid-inducible E3 protein), LAPTM5, of 262 aas and 5 TMSs. It is transactivated by RUNX2 and involved in RANKL trafficking in osteoblastic cells (Geng et al. 2019). t is down regluated in human cancer cells (Nuylan et al. 2016).

Accession Number:Q13571
Protein Name:Lysosomal-associated transmembrane protein 5
Length:262
Molecular Weight:29937.00
Species:Homo sapiens (Human) [9606]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Lysosome membrane1 / Multi-pass membrane protein2
Substrate

Cross database links:

Entrez Gene ID: 7805   
Pfam: PF03821   
KEGG: hsa:7805   

Gene Ontology

GO:0005887 C:integral to plasma membrane
GO:0005765 C:lysosomal membrane
GO:0005764 C:lysosome
GO:0006810 P:transport

References (3)

[1] “LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells.”  Adra C.N.et.al.   8661146
[2] “Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.”  Nagase T.et.al.   7788527
[3] “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”  The MGC Project Teamet.al.   15489334

External Searches:

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Predict TMSs (Predict number of transmembrane segments)
Window Size: Angle:  
FASTA formatted sequence 
1:	MDPRLSTVRQ TCCCFNVRIA TTALAIYHVI MSVLLFIEHS VEVAHGKASC KLSQMGYLRI 
61:	ADLISSFLLI TMLFIISLSL LIGVVKNREK YLLPFLSLQI MDYLLCLLTL LGSYIELPAY 
121:	LKLASRSRAS SSKFPLMTLQ LLDFCLSILT LCSSYMEVPT YLNFKSMNHM NYLPSQEDMP 
181:	HNQFIKMMII FSIAFITVLI FKVYMFKCVW RCYRLIKCMN SVEEKRNSKM LQKVVLPSYE 
241:	EALSLPSKTP EGGPAPPPYS EV