2.A.82.1.9
TMEM184A of 413 aas and 7 TMSs. Heparin decreases the tumor necrosis factor alpha (TNFalpha)-induced endothelial stress responses in vascular smooth muscle cells, and these responses require transmembrane protein 184A as well as induction of dual specificity phosphatase 1 (Farwell et al. 2016). Thus, TMEM184A functions as a heparin receptor and mediates anti-inflammatory responses.
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| Accession Number: | Q6ZMB5 |
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| Protein Name: | Transmembrane protein 184A |
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| Length: | 413 |
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| Molecular Weight: | 45777.00 |
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| Species: | Homo sapiens (Human) [9606] |
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| Number of TMSs: | 7 |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Multi-pass membrane protein2 |
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| Substrate |
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1: MSNVSGILET AGVPLVSANW PQPSPPPAVP AGPQMDHMGN SSQGAPWLFL TSALARGVSG
61: IFVWTALVLT CHQIYLHLRS YTVPQEQRYI IRLLLIVPIY AFDSWLSLLL LGDHQYYVYF
121: DSVRDCYEAF VIYSFLSLCF QYLGGEGAIM AEIRGKPIKS SCLYGTCCLR GMTYSIGFLR
181: FCKQATLQFC LVKPVMAVTT IILQAFGKYH DGDFNVRSGY LYVTLIYNAS VSLALYALFL
241: FYFTTRELLR PFQPVLKFLT IKAVIFLSFW QGLLLAILER CGVIPEVETS GGNKLGAGTL
301: AAGYQNFIIC VEMLFASVAL RYAFPCQVYA EKKENSPAPP APMQSISSGI RETVSPQDIV
361: QDAIHNFSPA YQHYTQQATH EAPRPGTHPS GGSGGSRKSR SLEKRMLIPS EDL