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2.A.85.2.1
An inorganic anion (Cl-/NO3-) transporter, ALMT12 or QUAC1 (Quickly activating Anion Channel 1), reported to be incapable of transporting organic anions, is involved in stomatal closure (Sasaki et al, 2010). It is an R-type inorganic anion channel required for stomatal movement in Arabidopsis guard cells (Meyer et al., 2010).  The C-terminal cytosolic domain mediates voltage gating (Mumm et al. 2013). QUAC1 regulates stomatal closure in response to environmental stimuli (Qin et al. 2022). See Dabravolski and Isayenkov 2023 for a review of the ALMT subfamiily.

Accession Number:O49696
Protein Name:Orf1
Length:560
Molecular Weight:62310.00
Species:Arabidopsis thaliana (Mouse-ear cress) [3702]
Number of TMSs:5
Location1 / Topology2 / Orientation3: Cell inner membrane1 / Multi-pass membrane protein2
Substrate chloride, nitrate

Cross database links:

RefSeq: NP_193531.1   
Entrez Gene ID: 827522   
Pfam: PF11744   
KEGG: ath:AT4G17970   

Gene Ontology

GO:0012505 C:endomembrane system
GO:0008509 F:anion transmembrane transporter activity
GO:0010044 P:response to aluminum ion
GO:0010118 P:stomatal movement

References (1)

[1] “Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.”  Mayer K.F.X.et.al.   10617198

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MSNKVHVGSL EMEEGLSKTK WMVLEPSEKI KKIPKRLWNV GKEDPRRVIH ALKVGLSLTL 
61:	VSLLYLMEPL FKGIGSNAIW AVMTVVVVLE FSAGATLCKG LNRGLGTLIA GSLAFFIEFV 
121:	ANDSGKVLRA IFIGTAVFII GAAATYIRFI PYIKKNYDYG VVIFLLTFNL ITVSSYRVDS 
181:	VINIAHDRFY TIAVGCGICL FMSLLVFPIW SGEDLHKTTV GKLQGLSRSI EACVDEYFEE 
241:	KEKEKTDSKD RIYEGYQAVL DSKSTDETLA LYANWEPRHT LRCHRFPCQQ YVKVGAVLRQ 
301:	FGYTVVALHG CLQTEIQTPR SVRALFKDPC VRLAGEVCKA LTELADSISN HRHCSPEILS 
361:	DHLHVALQDL NSAIKSQPKL FLGSNLHRHN NKHQNGSISN NKHHQRNSSN SGKDLNGDVS 
421:	LQNTETGTRK ITETGSRQGQ NGAVSLSSFR TDTSALMEYR RSFKNSNSEM SAAGERRMLR 
481:	PQLSKIAVMT SLEFSEALPF AAFASLLVEM VARLDNVIEE VEELGRIASF KEYDNKRDQT 
541:	ADDVRCENPA NVTISVGAAE