2.A.85.2.5
Aluminum-stimulated anion (Malate >> NO3- > Cl-; Malate/Cl- ≈ 20) channel (Zhang et al., 2008) (67% identical to 2.A.85.2.4). Confers Al+3 resistance (Ryan et al., 2011). May also transport a variety of organic and inorganic anions (Piñeros et al. 2008). It can also transport GABA (Ramesh et al. 2018). ALMT1 has 6 TMSs with the N- and C-termini being on the external surface of the plasma membrane (Motoda et al. 2007).
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| Accession Number: | Q76LB2 |
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| Protein Name: | ALMT1 |
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| Length: | 459 |
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| Molecular Weight: | 49673.00 |
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| Species: | Triticum aestivum (Wheat) [4565] |
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| Number of TMSs: | 6 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
chloride, malate(2-), nitrate |
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| Pfam: |
PF11744
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[1] “A wheat gene encoding an aluminum-activated malate transporter.” Sasaki T. et.al. 14871306
[2] “Molecular characterization and mapping of ALMT1, the aluminium-tolerance gene of bread wheat (Triticum aestivum L.).” Raman H. et.al. 16391684
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1: MDIDHGRESD GEMVGTIASC GLLLHSLLAG LGRRAAGFAR KVGGAAREDP RRVAHSLKVG
61: LALALVSVVY FVTPLFNGLG VSAIWAVLTV VVVMEYTVGA TLSKGLNRAL ATLVAGCIAV
121: GAHQLAELAE RCGDQGEPIM LTVLVFFVAS AATFLRFIPE IKAKYDYGVT IFILTFGLVA
181: VSSYRVEELI QLAHQRFYTI AVGVFICLCT TVFLFPVWAG EDVHKLASGN LDKLAQFIEG
241: MEFNCFGENS VANNFGGKDF PQMHKSVLNS KATEDSLCTF AKWEPRHGQF RFRHPWSQYQ
301: KLGTLCRQCA SSMEALASYV ITTSKTQCPA AANPELSCKV RKTCGEMSLH SSKVLRDLAM
361: ATRTMTVPSP VNITMATAVK AAESLRSELA ENTALLQVMH VAVTATLLAD LVDRVKEIAE
421: CVDVLARLAH FKNPEDTKNV VVSTVSRGID EPLPDVVIL