2.A.86.3.1
Protein belonging to family UPF0118, NhaM, of 384 aas and 3 or 4 N-terrminal TMSs. Members of this family were functionally characterized as Na+, Li+, K+/H+ anitiporters by Shao et al. 2020, but the family was first identified by Dong et al. 2017. Shao et al. 2020 showed that a small region of 104 aas and 3 TMSs was sufficient for antiport activity following oligomerization. The N-terminal hydrophobic domain is the only one showing homology with other members of the family.
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| Accession Number: | M5RNE9 |
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| Protein Name: | Protein belonging to Uncharacterized protein family UPF0118 |
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| Length: | 384 |
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| Molecular Weight: | 42667.00 |
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| Species: | Rhodopirellula maiorica SM1 [1265738] |
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| Number of TMSs: | 1 |
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| Location1 / Topology2 / Orientation3: |
Membrane1 / Multi-pass membrane protein2 |
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| Substrate |
lithium(1+), sodium(1+), potassium(1+), hydron |
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1: MLFPLLVSVA TSTGWTQPIA VLVFFTVSEL ATGNVIEPVL FGKTTGLTPI ALLVAALFWA
61: WIWGPVGLLL STPLTVCLVV LGQHLPHLRS LKVLLAEQPV LDARLQFFQR LLAQDLVEGR
121: RVYKQYANEF GQERAFDEVL IPALSWTRIE RGKESISAAE EQFIWKATRD SFDLDESEQA
181: EVPERGAAKN EAATNHSTKN DDRSSLENQR HIDAADDDDV CVPTPPRRRL FGHPVHHESE
241: EIALAMLSRL VEDDCDVELS TTKELPSKVV SKISQCHPDI VVLTVLPPGG LPQLKYMCNE
301: IRSSQPTVPI VVTYLGQMKD YDELLVRIRD AGASYLTTSL AQTKHQIDVL LKDLNQADTN
361: GSACDRSRPV DAEETNREEA SHVS