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|---|---|
| Accession Number: | P47818 |
| Protein Name: | Ccc1 aka YLR220W |
| Length: | 322 |
| Molecular Weight: | 34250.00 |
| Species: | Saccharomyces cerevisiae (Baker's yeast) [4932] |
| Number of TMSs: | 5 |
| Location1 / Topology2 / Orientation3: | Golgi apparatus membrane1 / Multi-pass membrane protein2 |
| Substrate | iron(2+), manganese(2+) |
Cross database links:
| DIP: | DIP-782N |
|---|---|
| RefSeq: | NP_013321.1 |
| Entrez Gene ID: | 850917 |
| Pfam: | PF01988 |
| KEGG: | sce:YLR220W |
Gene Ontology
GO:0000329
C:fungal-type vacuole membrane
GO:0000139
C:Golgi membrane
GO:0016021
C:integral to membrane
GO:0015093
F:ferrous iron transmembrane transporter acti...
GO:0005384
F:manganese ion transmembrane transporter act...
GO:0005515
F:protein binding
GO:0006874
P:cellular calcium ion homeostasis
GO:0006879
P:cellular iron ion homeostasis
GO:0030026
P:cellular manganese ion homeostasis
GO:0015684
P:ferrous iron transport
GO:0006828
P:manganese ion transport
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References (19)[1] “Sequence, mapping and disruption of CCC1, a gene that cross-complements the Ca(2+)-sensitive phenotype of csg1 mutants.” Fu D.et.al. 7941738 [2] “The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.” Johnston M.et.al. 9169871 [3] “Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.” Hu Y.et.al. 17322287 [4] “The product of HUM1, a novel yeast gene, is required for vacuolar Ca2+/H+ exchange and is related to mammalian Na+/Ca2+ exchangers.” Pozos T.C.et.al. 8668190 [5] “The role of the Saccharomyces cerevisiae CCC1 gene in the homeostasis of manganese ions.” Lapinskas P.J.et.al. 8866476 [6] “CCC1 suppresses mitochondrial damage in the yeast model of Friedreich's ataxia by limiting mitochondrial iron accumulation.” Chen O.S.et.al. 10713071 [7] “CCC1 is a transporter that mediates vacuolar iron storage in yeast.” Li L.et.al. 11390404 [8] “Phosphoproteome analysis by mass spectrometry and its application to Saccharomyces cerevisiae.” Ficarro S.B.et.al. 11875433 [9] “Global analysis of protein localization in budding yeast.” Huh W.-K.et.al. 14562095 [10] “Global analysis of protein expression in yeast.” Ghaemmaghami S.et.al. 14562106 [11] “A proteomics approach to understanding protein ubiquitination.” Peng J.et.al. 12872131 [12] “A mitochondrial-vacuolar signaling pathway in yeast that affects iron and copper metabolism.” Li L.et.al. 15161905 [13] “Coordinated remodeling of cellular metabolism during iron deficiency through targeted mRNA degradation.” Puig S.et.al. 15652485 [14] “A global topology map of the Saccharomyces cerevisiae membrane proteome.” Kim H.et.al. 16847258 [15] “Golgi manganese transport is required for rapamycin signaling in Saccharomyces cerevisiae.” Devasahayam G.et.al. 17603109 | |
External Searches:
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Analyze:
| Predict TMSs (Predict number of transmembrane segments) | ||||
| FASTA formatted sequence |
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1: MSIVALKNAV VTLIQKAKGS GGTSELGGSE STPLLRGSNS NSSRHDNLSS SSSDIIYGRN 61: SAQDLENSPM SVGKDNRNGD NGSDNEKANL GFFQSVDPRV ISDLIIGLSD GLTVPFALTA 121: GLSSLGDAKL VITGGFAELI SGAISMGLGG YLGAKSESDY YHAEVKKEKR KFYDNSNLIN 181: REIEDILLEI NPNFSDETIV SFIKDLQRTP ELMVDFIIRY GRGLDEPAEN RELISAVTIG 241: GGYLLGGLVP LVPYFFVSDV GTGLIYSIIV MVVTLFWFGY VKTKLSMGSG SSTSKKVTEG 301: VEMVVVGGVA AGAAWFFVKL LG