2.A.89.1.13
Vacuolar ferrous iron transporter, VIT, of 273 aas and 5 TMSs in a 2 + 3 TMS arrangement.  A new model for parasite iron homeostasis, in which PfE140 is involved in iron uptake across the plasma membrane, PfMRS3 ensures non-redundant Fe²⁺ supply to the mitochondrion as the main site of iron utilization, PfVIT transports excess iron into cytoplasmic vesicles, and PfZIPCO exports Fe²⁺ from these organelles in case of iron scarcity (Wunderlich et al. 2024). Only VIT was available in NCBI at the time this discussion was enterred into TCDB. PfNRAMP/PfDMT1 and PfCRT have previously reported to efflux Fe²⁺ from the digestive vacuole (Wunderlich et al. 2024).