| TCID | Name | Domain | Kingdom/Phylum | Protein(s) |
|---|---|---|---|---|
|
2.A.89.1.1 | The vacuolar Fe2+/Mn2+ uptake transporter, Ccc1 | Eukaryota |
Fungi, Ascomycota | Ccc1 of Saccharomyces cerevisiae (322 aas; P47818) |
|
2.A.89.1.2 | The vacuolar Fe2+ uptake transporter, VIT1 of 250 aas and 5 putative TMSs (Gollhofer et al. 2011). The crystal structure of the orthogous VIT1 from rose gum, Eucalyptus grandis, which probably functions as a H+-dependent antiporter for Fe2+ and other transition metal ions, has been solved. VIT1 adopts a novel protein fold forming a dimer of five membrane-spanning domains, with an ion-translocating pathway constituted by the conserved methionine and carboxylate residues at the dimer interface. The second transmembrane helix protrudes from the lipid membrane by about 40 Å, and connects to a three-helical bundle, triangular, cytoplasmic domain, which binds to the substrate metal ions in preparation for their transport (Kato et al. 2019). | Eukaryota |
Viridiplantae, Streptophyta | VIT1 of Arabidopsis thaliana (Q9ZUA5) |
|
2.A.89.1.3 | Uncharacterized protein of 242 aas and 5 TMSs | Bacteria |
Bacteroidota | Uncharacterized protein of Marivirga tractuosa |
|
2.A.89.1.4 | Uncharacterized protein of 252 aas with 5 TMSs | Bacteria |
Chlamydiota | Uncharacterized protein of Parachlamydia acanthamoebae |
|
2.A.89.1.5 | CCC1 (VIT) family protein of 248 aas and probably 5 TMSs in a 2 + 3 TMS arrangement. | Bacteria |
Chlamydiota | VIT family protein of Chlamydia trachomatis |
|
2.A.89.1.6 | Uncharacterized protein of 173 aas and 5 TMSs. | Bacteria |
Candidatus Sungbacteria | UP of Candidatus Sungbacteria bacterium |
|
2.A.89.1.7 | VIT family protein of 192 aas and 5 TMSs in a 2 + 3 TMS arrangement | Archaea |
Euryarchaeota | VIT protein of Methanobacterium sp. |
|
2.A.89.1.8 | Uncharacterized protein of 183 aas and 5 TMSs in a 2 + 3 TMS arrangement. | Archaea |
Thermoproteota | UP of Sulfolobus sp. A20 |
|
2.A.89.1.9 | Uncharacterized protein of 194 aas and 5 TMSs. | Bacteria |
Pseudomonadota | UP of Nitrosococcus halophilus |
|
2.A.89.1.10 | VIT family protein, partial, of 214 aas and 5 TMSs | Archaea |
Candidatus Lokiarchaeota | VIT family protein of Lokiarchaeum sp. GC14_75 (marine sediment metagenome) |
|
2.A.89.1.11 | Uncharacterized VIT family protein of 222 aas and 5 TMSs in a 2 + 3 TMS arrangement. | Archaea |
Candidatus Thorarchaeota | UP of Candidatus Thorarchaeota archaeon AB_25 (marine sediment metagenome) |
|
2.A.89.1.12 | Uncharacterized protein of 203 aas and 5 TMSs in a 2 + 3 TMS arrangement. | Archaea |
Candidatus Odinarchaeota | UP of Candidatus Odinarchaeota archaeon LCB_4 (hot springs metagenome) |
|
2.A.89.1.13 | Vacuolar ferrous iron transporter, VIT, of 273 aas and 5 TMSs in a 2 + 3 TMS arrangement. | Eukaryota |
Apicomplexa | Iron transporter of Plasmodium falciparum |
|
2.A.89.2.1 | Member of rubrerythrin family of electron transporters; of 327 aas and 5 TMSs. | Bacteria |
Pseudomonadota | VIT family member of Rhizobium leguminosarum |
|
2.A.89.2.2 | Membrane-bound ferritin-like ferrous iron (Fe2+) exporter, MbfA, of the erythrin-vacuolar iron transport-1 (Er-VIT1) family of 327 aas. The protein has an N-terminal ferritin domain and a C-terminal VIT domain of 5 established TMSs (Bhubhanil et al. 2014). | Bacteria |
Pseudomonadota | MbfA of Agrobacterium tumefaciens |
|
2.A.89.2.3 | VIT family member of 2690 aas and 5 TMSs. | Bacteria |
Pseudomonadota | VIT of Bartonella clarridgeiae |
|
2.A.89.3.1 | The bacterial VIT family homologue | Bacteria |
Pseudomonadota | VIT homologue of Burkholderia phytofirmans (376 aas; B2TCH9) |
|
2.A.89.3.2 | VIT family member, Spr0814 (Becker et al., 2009). | Bacteria |
Bacillota | Spr0814, VIT family member of Streptococcus pneumoniae (E1H0W3) |
|
2.A.89.3.3 | Vacuolar Nodulin-like1 (At1g21140) Iron regulated (Gollhofer et al., 2011). | Eukaryota |
Viridiplantae, Streptophyta | VIT homolog1 of Arabidopsis thaliana (Q9LPU9) |
|
2.A.89.3.4 | Nodulin-like2 (At1g76800) Iron regulated (Gollhofer et al., 2011). | Eukaryota |
Viridiplantae, Streptophyta | VIT homolog2 of Arabidopsis thaliana (Q9SR03) |
|
2.A.89.3.5 | Nodulin-like2.1 (At3g25190) Iron regulated; involved in Fe homeostasis (Gollhofer et al., 2011). | Eukaryota |
Viridiplantae, Streptophyta | VIT homolog2.1 of Arabidopsis thaliana (Q9LSF6) |
|
2.A.89.3.6 | Nodulin-like3 (At3g43630) Not iron regulated; involved in Fe homeostasis (Gollhofer et al., 2011). | Eukaryota |
Viridiplantae, Streptophyta | VIT3 of Arabidopsis thaliana (Q9M2C3) |
|
2.A.89.3.7 | Nodulin-like4 (At3g43660) Not iron regulated (Gollhofer et al., 2011). | Eukaryota |
Viridiplantae, Streptophyta | VIT4 of Arabidopsis thaliana (Q9M2C0) |
|
2.A.89.3.8 | Fe2+/Mn2+ transporter Pcl1 (Pombe ccc1-like protein 1) | Eukaryota |
Fungi, Ascomycota | Pcl1 of Schizosaccharomyces pombe |
|
2.A.89.3.9 | VIT family protein of 413 aas with an N-terminal rubrerythrin-like (ferritin-like) domain and a C-terminal DUF125 (5 TMS) domain. | Bacteria |
Verrucomicrobiota | VIT family protein of Methylacidiphilum infernorum (Methylokorus infernorum) |
|
2.A.89.3.10 | The archaeal VIT family homologue | Archaea |
Euryarchaeota | VIT homologue of Pyrococcus abyssi (364 aas; CAB50539) |