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2.A.9.3.2
Essential sporulation inner membrane protein, SpoIIIJ is a proposed membrane protein translocase that facilitates the insertion of SpoIIIAE into the membrane (Camp and Losik, 2008). Also facilitates membrane insertion of F-ATPase subunit c from B. subtilis and E. coli. Plays a role in membrane protein biogenesis rather than protein secretion (Saller et al., 2009).

Accession Number:Q01625
Protein Name:SpoIIIJ
Length:261
Molecular Weight:29522.00
Species:Bacillus subtilis [1423]
Number of TMSs:6
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate protein polypeptide chain

Cross database links:

RefSeq: NP_391984.1   
Entrez Gene ID: 937934   
Pfam: PF02096   
KEGG: bsu:BSU41040   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0051205 P:protein insertion into membrane
GO:0030435 P:sporulation resulting in formation of a cel...

References (7)

[1] “Structure and function of the spoIIIJ gene of Bacillus subtilis: a vegetatively expressed gene that is essential for sigma G activity at an intermediate stage of sporulation.”  Errington J.et.al.   1487728
[2] “Genes and their organization in the replication origin region of the bacterial chromosome.”  Ogasawara N.et.al.   1552862
[3] “Systematic sequencing of the 180 kilobase region of the Bacillus subtilis chromosome containing the replication origin.”  Ogasawara N.et.al.   7584024
[4] “The complete genome sequence of the Gram-positive bacterium Bacillus subtilis.”  Kunst F.et.al.   9384377
[5] “Analysis of the Bacillus subtilis spoIIIJ gene and its paralogue gene, yqjG.”  Murakami T.et.al.   11889108
[6] “Complementary impact of paralogous Oxa1-like proteins of Bacillus subtilis on post-translocational stages in protein secretion.”  Tjalsma H.et.al.   12586834
[7] “Expression of spoIIIJ in the prespore is sufficient for activation of sigma G and for sporulation in Bacillus subtilis.”  Serrano M.et.al.   12813085

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence 
1:	MLLKRRIGLL LSMVGVFMLL AGCSSVKEPI TADSPHFWDK YVVYPLSELI TYVAKLTGDN 
61:	YGLSIILVTI LIRLLILPLM IKQLRSSKAM QALQPEMQKL KEKYSSKDQK TQQKLQQETM 
121:	ALFQKHGVNP LAGCFPILIQ MPILIGFYHA IMRTQAISEH SFLWFDLGEK DPYYILPIVA 
181:	GVATFVQQKL MMAGNAQQNP QMAMMLWIMP IMIIVFAINF PAALSLYWVV GNLFMIAQTF 
241:	LIKGPDIKKN PEPQKAGGKK K