2.A.92.1.10
Choline transporter 1, CHER1, CLT1, SIC1, of 700 aas and 9 TMSs in a 1 + 2 + 2 + 2 + 2 TMS arrangement. It is a choline transporter involved in the regulation of choline metabolite homeostasis during root and phloem development (Dettmer et al. 2014). It is also a regulator of vesicle trafficking, including endocytosis, and is necessary for
secondary plasmodesmata (PD) formation and development via the secretory
trafficking regulation of proteins required for PD development, thus
influencing intercellular communication (Kraner et al. 2017, Gao et al. 2017). It is required for procambium maintenance and sieve plate development (e.g.
sieve plate and sieve pore elaboration) to mediate long-distance
cell-to-cell communication via symplastic transport through the phloem (Dettmer et al. 2014).
|
| Accession Number: | Q94AN2 |
|---|
| Protein Name: | Choline transporter protein 1 |
|---|
| Length: | 700 |
|---|
| Molecular Weight: | 78737.00 |
|---|
| Species: | Arabidopsis thaliana (Mouse-ear cress) [3702] |
|---|
| Number of TMSs: | 9 |
|---|
| Location1 / Topology2 / Orientation3: |
Early endosome membrane1 / Multi-pass membrane protein2 |
|---|
| Substrate |
choline |
|---|
1: MRGPLGAVIG RYTSSDGSAP NDGIIKHNRK CRDITFLIIF IAFWVSMIVN SSFGFNQGNP
61: LRLTYGLDYE GNVCGSKHRH RDLTQLELRY WLNPNQVYES GLKDGELKLA NARTICLLDC
121: PAPSDDTLNW VCDYPDGEIR LKMNDWIDRN YDYFEFLTPE MRNSSLQLQG PCYPVIFPSV
181: NVYWSCQYIA RASNSSLRHW QQMGGVNIQE DMIIDKSIRR SMNSRASVLK RYVADIGKSW
241: PVLIVCGGLV PLFLSIIWLL LIRHFVAAMP WITVVLFNML LISVTVFYYL KAGWIGNDAV
301: TPIIGEHDPY FHVYGRELTH VRGVAILMTF ISVVAILTSI AIIRRILMAT SVLKVAAKVI
361: GEVQALIIFP AIPFAMLAIF YMFWISAALH LFSSGQVVQN NCNNTNCCAY DLVLKKVNCD
421: RCCGYSIHYT PHITIAIFFH LFGCYWATQF FIASSATVIA GSVASYYWAQ GEASPEIPFL
481: PVFASMKRLA RYNLGSVALG SLIVSFVESV RFILEAIRRK TKVSGTIPDH WFWRMAHYTS
541: RGCLKSVEWT IKSVNRNAYI MIAITGKSFC KSSAIATELI ISNILRIGKV NVIGDVILFL
601: GKLCVSLFSA LFGFLMLDSH RYRASHNKVS SPLLPVLACW ALGYIVATLF FAVVEMSIDT
661: IILSFCQDSE ENQGNAQHAP PLLLETLDSN QEEEVQSLTH