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3.A: P-P-bond-hydrolysis-driven transporters
P-P-bond hydrolysis-driven transporters. Transport systems are included in this subclass if they hydrolyze the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate, to drive the active uptake and/or extrusion of a solute or solutes. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated.
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3.A.1 The ATP-binding Cassette (ABC) Superfamily
3.A.2 The H+- or Na+-translocating F-type, V-type and A-type ATPase (F-ATPase) Superfamily
3.A.3 The P-type ATPase (P-ATPase) Superfamily
3.A.4 The Arsenite-Antimonite (ArsAB) Efflux Family
3.A.5 The General Secretory Pathway (Sec) Family
3.A.6 The Type III (Virulence-related) Secretory Pathway (IIISP) Family
3.A.7 The Type IV (Conjugal DNA-Protein Transfer or VirB) Secretory Pathway (IVSP) Family
3.A.8 The Mitochondrial Protein Translocase (MPT) Family
3.A.9 The Chloroplast Envelope Protein Translocase (CEPT or Tic-Toc) Family
3.A.10 The H+, Na+-translocating Pyrophosphatase (M+-PPase) Family
3.A.11 The Bacterial Competence-related DNA Transformation Transporter (DNA-T) Family
3.A.12 The Septal DNA Translocator (S-DNA-T) Family
3.A.13 The Filamentous Phage Exporter (FPhE) Family
3.A.14 The Fimbrilin/Protein Exporter (FPE) Family
3.A.15 The Outer Membrane Protein Secreting Main Terminal Branch (MTB) Family
3.A.16 The Endoplasmic Reticular Retrotranslocon (ER-RT) Family
3.A.17 The Phage T7 Injectisome (T7 Injectisome) Family
3.A.18 The Nuclear mRNA Exporter (mRNA-E) Family
3.A.19 The Guided Entry of Tail Anchored Protein (GET) Family
3.A.20 The Peroxisomal Protein Importer (PPI) Family
3.A.21 The C-terminal Tail-Anchored Membrane Protein Biogenesis/ Insertion Complex (TAMP-B) Family
3.A.22 The Transcription-coupled TREX/TAP Nuclear mRNA Export Complex (TREX) Family
3.A.23 The Type VI Symbiosis/Virulence Secretory System (T6SS) Family
3.A.24 The Type VII or ESX Protein Secretion System (T7SS) Family
3.A.25 The Symbiont-specific ERAD-like Machinery (SELMA) Family
3.A.26 The Plasmodium Translocon of Exported proteins (PTEX) Family
3.A.27 The Endoplasmic Reticulum Membrane Protein Insertion Complex (EMC) Family
3.A.28 The AAA-ATPase, Bcs1 (Bcs1) Family
3.A.29 The Mitochondrial Inner Membrane i-AAA Protease Complex (MIMP) Family
3.A.30 The Endoplasmic Reticulum Surface Retrieval Pathway (ER-SURF) Family
3.A.31 The Endosomal Sorting Complexes Required for Transport III (ESCRT-III) Family
3.A.32 The Mitochondrial Outer Membrane-associated Protein Degradation (MOM-APD) Family
3.A.33 The BBSome Complex (BBSome) Family
3.A.34 The Sorting Nexins of the ESCRT Complexes (SN-ESCRT)
3.A.35 The Trypanosoma Archaic Translocase of the Outer Membrane (T-ATOM) Family