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3.A.1.1.51
Maltose - maltoheptaose transporter, MalEFGK.  MalEF is a R-M fusion protein with the MalE domain N-terminal and the MalF domain C-terminal. The protein, of 733 aas, has 8 TMSs, one N-terminal to MalE (a signal sequence for export of the MalE domain to the periplasm), an extra TMS at the N-terminus to bring the N-terminus to the periplasmic side of the inner membrane, and then the usual 6 TMSs observed for many ABC membrane proteins.  MalG (M, 272 aas, 6 TMSs) and MalK (C, 374 aas) are of normal size and composition. While MalE of E. coli was able to additionally increase ATPase activity of MalFGK2 in vitro, the isolated MalE domain of B. bacteriovorus failed to stimulate the E. coli system (Licht et al. 2018). The adjacent genes are an α-amylase (Q6MNM3) and a glucokinase (Q6MNM4).

Accession Number:Q6MNM0
Protein Name:Maltose/maltodextrin transport permease homologue
Length:733
Molecular Weight:82400.00
Species:Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIB 9529 / HD100) [264462]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell membrane1 / Multi-pass membrane protein2
Substrate alpha,alpha-trehalose, alpha-cyclodextrin, maltose, alpha-maltotriose, maltotetraose, maltoheptaose heptasaccharide, maltopentaose pentasaccharide

Cross database links:

Structure:
6FFL     

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MKFWILPFLI FASLTARAED VRIQIWHQMI YGHRQVLAEA LEKFEKENPG ITVQATYRET 
61:	EELRSSFQSA AMGGSGPELV YGPSDQVGPF ATMGIVRPLD EVLGSDYFQN FDPLAAPVYD 
121:	GKHYMIGDAV GNHLMLLYNK KFITTPPKNS QELIELGKKM TVDTNGDGKI DRWGLVFNYT 
181:	EPFFFAPFIP AFGEAFLKAD GVTPNLNTTA LKDTFQFILK LRDQDKIIPK ECDYETANAL 
241:	FKENKAAMLI NGDWSWGDYQ QAKVDFGIAR IPMISETGKW PSPLVGTKGY SLNANMKSEA 
301:	HYEAAVKLLK YLTSTPVQLL FAEKVGVLPS NLQARESDIV KNNPLLKISA DIMEVGTPMP 
361:	VTPEVRAVWD SLRIQYQKVL AGSLQPQAAA EQAQITAEQQ IRDMNEVLTP GVGATVLKVI 
421:	FGIGIVLLIW LTRNSLVAFF KGFRGPQRFA YYMMLPAFIG IFAVIIYPFF YNIAISFSNF 
481:	SLRTFQDWSL VGFHHYIAAL SDPRFYSLFL KTVIWTVVNI VFHVSIGVFL AVIINQVIAG 
541:	KGFWRALLII PWAVPQYITA LTWRAMFNQE YGPINIFLQQ FLHMSPVQWL SQPTTAFAAC 
601:	ILTNVWLGFP FMMIVALGGL QSIPSSLYEA ARLDGANAWQ RFRHITWPLL LPVMAPAALL 
661:	GSIWTFNNLN VIWLVSNSGE PGDQTHILVS YVYKAAFNLY RYGYAASVSV IIFLILVIWG 
721:	LGSLKSQFKK ETK