3.A.1.12.20
Thiol-containing reducing agent transporter, EgtUBC of two proteins, the transmembrane protein of 506 aas and 7 TMSs with a  fused external C-terminal binding protein domain, and an ATPase of 242 aas.  Ergothioneine (EGT) is a natural betaine amino acid found in various foods, particularly mushrooms (Wen et al. 2025).  A review of the antioxidant ergothioneine has appeared, focusing on its biosynthesis pathways, production, function and food applications (Zhang et al. 2025).  The intact bacterial ergothioneine transporter EgtUhas been expressed and purified (Edmonds et al. 2025).  Ergothioneine (EGT) decreased ROS production and promoted the expression of antioxidative enzymes to maintain redox homeostasis in sensory hair cells (Zhao et al. 2025).