3.A.1.120.4
Carbomycin resistance ATPase (membrane constituent unknown)
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| Accession Number: | Q60248 |
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| Protein Name: | CarA |
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| Length: | 551 |
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| Molecular Weight: | 60389.00 |
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| Species: | Streptomyces thermotolerans [80858] |
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| Location1 / Topology2 / Orientation3: |
Cell membrane1 / Peripheral membrane protein2 |
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| Substrate |
clarithromycin |
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| Pfam: |
PF00005
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[1] “Sequence similarity between macrolide-resistance determinants and ATP-binding transport proteins.” Schoner B. et.al. 1612454
[2] “Nucleotide sequence analysis of the carbomycin biosynthetic genes including the 3-O-acyltransferase gene from Streptomyces thermotolerans.” Arisawa A. et.al. 7772821
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1: MSTAQLALHD ITKRYQDHVV LDRIGFTIKP GEKVGVIGDN GSGKSTLIKL IAGREQPDNG
61: AVTVVAPGGV GYLAQTLELP LEATVQDAVD LALADLRELE EGMRRTEAEL AERPYQTGQD
121: PELAGLLESY AALVDRYQAR GGYEADSRVE IALHGLGLPG LERGRRLGTL SGGERSRLAL
181: AATLASEPEL LLLDEPTNDL DDRAVDWLEE HLRKHKGTVV AVTHDRLFLD RLTTTILEID
241: SGKVMRYGNG YEGYLAAKAA ERQRRLLEYE QWRAELDRSR DLIASNVARL DAIPRKLPFA
301: VFGAGQFRMR GRGHGAMVRI RNAKERVARL TENPVAPPPE PLTFTAEITT EAAQSRETVA
361: ELTGVRVGDR LSVDSLHLGP GERLLVTGPN GAGKTTLLRV LSGELEPDSG SLLVSGRVGH
421: LRQEQTPWRP GMTVLQAFSS GRAGDIDEHT EALLSLGLFS PDDLRQRVQD LSYGQRRRIE
481: LARLVTEPVD LLLLDEPTNH LSPALVEELE EALTGYQGTV VVVTHDRRMR SRFNGAHLTL
541: QDGRVAEFTA A