3.A.1.134.11 Lantibiotic detoxification ABC transporter, VraD (252 aas)/VraE (626 aas; 10 TMSs)/VraH ( (Draper et al. 2015). Upregulated in response to exposure to beta-defensin 3 (Sass et al. 2008). Exports antimicrobial peptides such as nisin, bacitracin, daptomycin and gallidermin. Expression of vraH in the absence of vraDE is sufficient to mediate
low-level resistance, but VraDEH is required to confer high-level
resistance against daptomycin and gallidermin. (Popella et al. 2016).
|
Accession Number: | Q9RL74 |
Protein Name: | ABC transporter |
Length: | 252 |
Molecular Weight: | 27775.00 |
Species: | Staphylococcus aureus [1280] |
Substrate |
daptomycin, bacitracin, alphaprodine |
---|
1: MTILSVQHVS KTYGKKHTFQ ALKDINFDIQ KGEFVAIMGP SGSGKTTLLN VLSSIDQISS
61: GSVIANGQEL NKLNQKALAK FRKESLGFIF QDYSILPTLT VKENIMLPLS VQKMSKATME
121: ENYKAITTAL GIYDLGNKYP SELSGGQQQR TAAARAFVHK PQIIFADEPT GALDSKSAND
181: LLQRLEEMNK SFDTTIVMVT HDPVAASFAE RVIMLKDGQI HTQLYQEGRS KQAFYEDIVH
241: LQSVLGGVSN DI