3.A.1.135.6
Two component multidrug efflux pump with the 6 TMS membrane domain preceding the ATPase domain in both proteins. Confers resistance to erythromycin and tetracycline and catalyzes export of Hoechst 33342 (Moodley et al. 2014). Expression is induced by the presence of erythromycin.
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| Accession Number: | E8MFM3 |
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| Protein Name: | Putative ABC transporter permease component |
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| Length: | 609 |
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| Molecular Weight: | 66670.00 |
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| Species: | Bifidobacterium longum subsp. longum (strain ATCC 15707 / DSM 20219 / JCM 1217 / NCTC 11818 / E194b) [565042] |
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| Number of TMSs: | 7 |
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| Substrate |
2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole, tetracycline, erythromycin A |
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1: MPRGPMGGRR AVEKPHDFGK VMGKLVNYCR NYLPVIIIAL ILGAAGTVCQ IVGPDKLKDM
61: TNEIVKGLPA IVNGRPVMNS VDFGTVGHIA WTLVALYVGY AVLGYVQSWM MANVTQRTAQ
121: RLRESISVKI NKLPLKYFDK VSYGDVLSRI TNDVDAIGQT LGQSLGSLIT SVTLFVGALV
181: MMFYNNVIMT LCAIGASLIG LIIMMAIMKS SQKYFARQQM ALGDVNGHVE EMYAGHLIVK
241: AYNGEADSIR RFEKYNSDLY ESGWKSQFLS GLMMPLMNFV GNFGYVVVCV VGAALALDGQ
301: IEFGVIVAFM MYVRLFTQPL AQFAQAFQNL QRCAAAAERV FGFLEEPEME DESGKSALLG
361: TNGHEVKGDV EFSHVQFGYE PGKPIIHDFS ASVKAGQKVA IVGPTGAGKT TMVNLLMRFY
421: EISGGSIAID GVDTKSVPRW NVHDQFSMVL QDTWVFRGTV RENIAYSKPG VTDKQIEDAC
481: KAVGLDHFIR SLPDGYDTVL DDKSSLSQGQ KQLLTIARAM VQDAPILILD EATSSVDTRT
541: EELIQKAMDA LTVGRTSFVI AHRLSTIRDA DMILVMNHGD VIERGTHDEL LAAGGFYADL
601: YNSQFALAD