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3.A.1.14.20
Heme-iron (hemin) utilization transporter BhuTUV ( Brickman et al., 2006; Vanderpool and Armstrong, 2004).  The crystal structures of BhuUV with or without the periplasmic haem-binding protein BhuT have been solved (Naoe et al. 2016). The TMSs show an inward-facing conformation, in which the cytoplasmic gate of the haem translocation pathway is completely open. Since this conformation is found in both the haem- and nucleotide-free form, the structure of BhuUV-T provides the post-translocation state and the missing piece in the transport cycle of type II importers.

Accession Number:Q7W024
Protein Name:Putative hemin permease
Length:311
Molecular Weight:32421.00
Species:bordetella pertussis [520]
Number of TMSs:7
Location1 / Topology2 / Orientation3: Cell outer membrane1
Substrate ferroheme b

Cross database links:

RefSeq: NP_879217.1   
Entrez Gene ID: 2664478   
Pfam: PF01032   
BioCyc: BPER257313:BP0344-MONOMER   
KEGG: bpe:BP0344   

Gene Ontology

GO:0016021 C:integral to membrane
GO:0005886 C:plasma membrane
GO:0005215 F:transporter activity
GO:0006810 P:transport

References (1)

[1] “Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica.”  Parkhill J.et.al.   12910271

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Predict TMSs (Predict number of transmembrane segments)
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FASTA formatted sequence
1:	MGILAAASGA VHIPLADLAR LIGGDSTPRD ALWRNVLFDI RLPRVLFAAT AGAALAICGA 
61:	AMQALFRNPL AEPGLVGISA GGAMGAVLAI VLTSGGFAIT APAAFAGSLL ATGCAYVLGR 
121:	RAHGVAGLLL AGIAINTVAG SVIGLLTFMA SDAQLRDLTF WSMGSLAGAR WSLLAFLAPW 
181:	TLLWSWWLMR QWRAMNALLL GEREAHHLGF ALRSVRRQLV LATALIVGPL VAATGGIGFV 
241:	GLVVPHLIRM TLGADHRWLL PASMLAGALA LTLADWLARV VIVPAELPIG LVTSLVGGPF 
301:	FLWLLARGRR L