TCDB » SEARCH

« See all members of the family

3.A.1.15.7 Manganese (Mn²⁺) (Km=0.1 μM) and iron (Fe²⁺) (5 μM) porter (inhibited by Cd²⁺ > Co²⁺ > Ni²⁺, Cu²⁺) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).
Accession Number:	Q9XCS1
Protein Name:	SitB aka STM2862
Length:	273
Molecular Weight:	29782.00
Species:	Salmonella typhimurium [90371]
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate	iron(2+), manganese(2+)

RefSeq:	NP_461783.1
Entrez Gene ID:	1254385
Pfam:	PF00005
BioCyc:	STYP99287:STM2862-MONOMER
KEGG:	stm:STM2862
Gene Ontology GO:0005524 F:ATP binding GO:0016887 F:ATPase activity
References (2) [1] “Salmonella typhimurium encodes a putative iron transport system within the centisome 63 pathogenicity island.” Zhou D.et.al. 10085045 [2] “Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.” McClelland M.et.al. 11677609

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MSQSAITVDQ VTVTYRNGHT ALRDATFQVP GGSIAALVGV NGSGKSTLFK ALMGFVHLAQ 
61:	GDITILQQSV NKALKKNLIA YVPQSEEVDW SFPVLVEDVV MMGRYGHMGW LRRPTAHDHA 
121:	CVDAALARVD MQEYRHRQIG ELSGGQKKRV FLARAIAQDG QVILLDEPFT GVDVKTEARI 
181:	IDLLRELRDE GRTMLVSTHN LGSVTEFCDY TVMIKGTVLA SGPTETTFTA ANLEQAFSGV 
241:	LRHIALSGGE EHIITDDERP FISRRVASGG KSS

3.A.1.15.7
Manganese (Mn²⁺) (Km=0.1 μM) and iron (Fe²⁺) (5 μM) porter (inhibited by Cd²⁺ > Co²⁺ > Ni²⁺, Cu²⁺) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

3.A.1.15.7Manganese (Mn2+) (Km=0.1 μM) and iron (Fe2+) (5 μM) porter (inhibited by Cd2+ > Co2+ > Ni2+, Cu2+) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).

Cross database links:

Gene Ontology

References (2)

External Searches:

Analyze:

3.A.1.15.7
Manganese (Mn²⁺) (Km=0.1 μM) and iron (Fe²⁺) (5 μM) porter (inhibited by Cd²⁺ > Co²⁺ > Ni²⁺, Cu²⁺) (most similar to YfeABCD of Yersinia pestis (TC #3.A.1.15.4)). Important for virulence in Salmonella (Karlinsey et al., 2010).