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3.A.1.2.8 Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)
Accession Number:	P77257
Protein Name:	LsrA(C)
Length:	511
Molecular Weight:	55821.00
Species:	Escherichia coli [83333]
Number of TMSs:	1
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Peripheral membrane protein²
Substrate

RefSeq:	AP_002134.1 NP_416030.1
Entrez Gene ID:	945680
Pfam:	PF00005
BioCyc:	EcoCyc:YDEX-MONOMER ECOL168927:B1513-MONOMER
KEGG:	ecj:JW1506 eco:b1513
Gene Ontology GO:0005886 C:plasma membrane GO:0005524 F:ATP binding GO:0016887 F:ATPase activity GO:0005515 F:protein binding GO:0006810 P:transport
References (5) [1] “A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map.” Aiba H.et.al. 9097039 [2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [4] “Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli.” Xavier K.B.et.al. 15601708 [5] “Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli.” Wang L.et.al. 15743955

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MQTSDTRALP LLCARSVYKQ YSGVNVLKGI DFTLHQGEVH ALLGGNGAGK STLMKIIAGI 
61:	TPADSGTLEI EGNNYVRLTP VHAHQLGIYL VPQEPLLFPS LSIKENILFG LAKKQLSMQK 
121:	MKNLLAALGC QFDLHSLAGS LDVADRQMVE ILRGLMRDSR ILILDEPTAS LTPAETERLF 
181:	SRLQELLATG VGIVFISHKL PEIRQIADRI SVMRDGTIAL SGKTSELSTD DIIQAITPAV 
241:	REKSLSASQK LWLELPGNRP QHAAGTPVLT LENLTGEGFR NVSLTLNAGE ILGLAGLVGA 
301:	GRTELAETLY GLRTLRGGRI MLNGKEINKL STGERLLRGL VYLPEDRQSS GLNLDASLAW 
361:	NVCALTHNLR GFWAKTAKDN ATLERYRRAL NIKFNQPEQA ARTLSGGNQQ KILIAKCLEA 
421:	SPQVLIVDEP TRGVDVSARN DIYQLLRSIA AQNVAVLLIS SDLEEIELMA DRVYVMHQGE 
481:	ITHSALTERD INVETIMRVA FGDSQRQEAS C

3.A.1.2.8
Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

3.A.1.2.8Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)

Cross database links:

Gene Ontology

References (5)

External Searches:

Analyze:

3.A.1.2.8
Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)