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3.A.1.2.8 Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)
Accession Number:	P77672
Protein Name:	LsrC(M)
Length:	342
Molecular Weight:	36395.00
Species:	Escherichia coli [83333]
Number of TMSs:	8
Location¹ / Topology² / Orientation³:	Cell inner membrane¹ / Multi-pass membrane protein²
Substrate

DIP:	DIP-11689N
RefSeq:	AP_002135.1 NP_416031.1
Entrez Gene ID:	946105
Pfam:	PF02653
BioCyc:	EcoCyc:YDEY-MONOMER ECOL168927:B1514-MONOMER
KEGG:	ecj:JW1507 eco:b1514
Gene Ontology GO:0016021 C:integral to membrane GO:0005886 C:plasma membrane GO:0005215 F:transporter activity GO:0006810 P:transport
References (6) [1] “A 570-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map.” Aiba H.et.al. 9097039 [2] “The complete genome sequence of Escherichia coli K-12.” Blattner F.R.et.al. 9278503 [3] “Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110.” Hayashi K.et.al. 16738553 [4] “Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli.” Xavier K.B.et.al. 15601708 [5] “Cyclic AMP (cAMP) and cAMP receptor protein influence both synthesis and uptake of extracellular autoinducer 2 in Escherichia coli.” Wang L.et.al. 15743955 [6] “Global topology analysis of the Escherichia coli inner membrane proteome.” Daley D.O.et.al. 15919996

UniProt (Universal Protein Resource)
CDD Search (Conserved Domain Database)

Predict TMSs (Predict number of transmembrane segments)

FASTA formatted sequence

1:	MLKFIQNNRE ITALLAVVLL FVLPGFLDRQ YLSVQTLTMV YSSAQILILL AMGATLVMLT 
61:	RNIDVSVGSI TGMCAVLLGM LLNAGYSLPV ACVATLLLGL LAGFFNGVLV AWLKIPAIVA 
121:	TLGTLGLYRG IMLLWTGGKW IEGLPAELKQ LSAPLLLGVS AIGWLTIILV AFMAWLLAKT 
181:	AFGRSFYATG DNLQGARQLG VRTEAIRIVA FSLNGCMAAL AGIVFASQIG FIPNQTGTGL 
241:	EMKAIAACVL GGISLLGGSG AIIGAVLGAW FLTQIDSVLV LLRIPAWWND FIAGLVLLAV 
301:	LVFDGRLRCA LERNLRRQKY ARFMTPPPSV KPASSGKKRE AA

3.A.1.2.8
Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

3.A.1.2.8Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)

Cross database links:

Gene Ontology

References (6)

External Searches:

Analyze:

3.A.1.2.8
Autoinducer-2 (AI-2, a furanosyl borate diester: (3aS,6S,6aR)-2,2,6,6a-tetrahydroxy-3a-methyltetrahydrofuro[3,2-d][1,3,2]dioxaborolan-2-uide) uptake porter (Taga et al., 2001, 2003)