3.A.1.200.51
ABCC4 efflux transporter exports C-glycosylated flavones (CGFs), which are the main flavonoids in duckweed
(Lemna turionifera), known for their diverse pharmacological activities
and nutritional values (Wang et al. 2024). The protein is of 1496 aas with 15 or 16 TMSs in a 5 or 6 + 6 + 6 TMS arrangement. The LtP1L transcription factor directly binds to a novel AC-like cis-element in the promoter of a
tonoplast-localized ATP-binding cassette (ABC) transporter LtABCC4 and
activated its expression. The preference of LtABCC4 for
isoorientin over orientin during vacuolar transport was evidenced by the
significant reduction of isoorientin compared to orientin in the
Ltabcc4crispr lines (Wang et al. 2024).
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| Accession Number: | WEG20082.1 |
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| Protein Name: | WEG20082.1 ABCC4 [Lemna turionifera] |
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| Length: | 1497 |
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| Molecular Weight: | |
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| Species: | Lemna turionifera [161106] |
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| Number of TMSs: | 17 |
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| Substrate |
flavonoid |
|---|
1: MLSGAASFGS LSRIASPVCN CEAASLSEWL RFFFLSPCPQ RVLSSAIDVV FLLFLSFVSV
61: QRLWRRVHLG NRNPPDLHKP LIEEQKPAAF RTNILYKLSL ILSAVLSISS AVFLVLSAVG
121: YGIWDPVEAL FLVSKALASL GAFILIAHEK RFQARTHALT LRLYWVASFL AASLLAASAV
181: LRFVNHGSEL FLDDIFSLGA FAISSFLLYG GITGKTGVVL VLSLVSEPAE DNATGFASAS
241: LFSRATFFWM DPVLKKGHKS PLKLTDVPSL APEHRAERMY ELFQSNWPSP ALRSNHPVRT
301: ALLRCFWPNL LLTACLSIAR LSVMYVGPLL INRFVDFATS KNQRSPLEGL YLCGILLAAK
361: SAEVICSHQY NFQSQKLGML IRSTLITSLY RKGLRLSCSS RQSHGVGQIV NYMAVDAQQL
421: SDMMLQLHYV WMMPVQVGTA VVLLYFRLGV AALAAALYIT VILIFVVMGT KRNNAYQFKL
481: MRMRDKRMKA TNEMLNYMRV IKFQAWEDHF NSRILKFREG EFAWLTKFFY SVSANTVALW
541: STTVMVSLTT FGTCLLFGVG LNAGTVFTAT ALFKILQEPL RNFPQALIQA SQAMISLERL
601: DAYMTSGELD ESAVEKFPGG CEDGVAVEVR EGAFNWDDEP TTASGGSLRN LNVQVKTGSL
661: AAVVGSVGSG KSSFLSCILG EMHRISGKVR VCGTTAYVAQ TAWIQNGTIQ ENILFGSPME
721: PERYEEVLRV CCLEKDMEMM DFGDQTEIGE RGINLSGGQK QRIQLARAVY QDSDVYLLDD
781: IFSAVDAQTG SFIFKECVRG ALKGKTVVLV THQVDFLHNA DLILVMRDGE IVQSGKYHQL
841: LAAGTDFSAL VAAHDNSMEL VEHGAATAGE VNDATPKPSE NPPPVQNHAE ARRDSTEIPK
901: KGKGTAKLIE EEQRETGRIG WSVYKTYATE AWGWWGLVSV TLATVLWQVS VVSGDNWLAI
961: ETSKENEASF NPVVFIRVYA VICGLVMVVI AIRTLLVTAL GLATAQIFFR QIIDSILHAP
1021: MSFFDTTPSG RILSRASSDQ TNIDLFLPLF ATLSLAMFMN VFSILVITCL VAWPTIVIII
1081: PLAVLNFWLR GYYLASSREL TRLDSITKAP VIHHFSESVS GVTTIRCFMK EESFSKENLS
1141: RVDSNLRMDF HNNGSNEWLG FRLEFIGSIV FCFSAFLIVI LPDSIVKPEY VGFSLSYGLS
1201: LNSVLFYAIW ISCLVENRMV SVERIKQFTN IPSEAAWRIE GCLPSASWPT RGNIDLRDLR
1261: VRYRPNTPMV LKGITLRING GEKIGVVGRT GSGKSTLIQA LFRVVEPSEG KIIIDGIDIS
1321: TLGLHDLRSR FGIIPQEPVL FEGTVRSNID PTGAHTDDEI WKSLERCQLK EVVSGKPEKL
1381: DSMVVDSGDN WSVGQRQLLC LGRVMLKRSP ILFMDEATAS VDSQTDAMIQ KIIREDFASC
1441: TIISIAHRIP TVMDCDRVLV VDAGLAAEFD APSNLIERPS LFGALVQEYA NRSSGL