3.A.1.201.15
MDR efflux pump, ABCB1a. Exports canonical MDR susbtrates such as calcein-AM, bodipy-verapamil, bodipy-vinblastine and mitoxantrone (Gokirmak et al. 2012).
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| Accession Number: | Q3T7C8 |
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| Protein Name: | Egg permeability glycoprotein |
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| Length: | 1329 |
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| Molecular Weight: | 144825.00 |
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| Species: | Strongylocentrotus purpuratus (Purple sea urchin) [7668] |
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| Number of TMSs: | 12 |
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| Substrate |
mitoxantrone, drug |
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1: MVEGDPPAVG FSNGNGTVQM NGNGASFDGP AVIDVSPVHE DAPSAKHARD SPPPAYNDVD
61: GTKEQENGGS VEGEGGEKEE KKETKVVGTF EVFRFATGLD VVFILLALVI SLCHGVALPA
121: VLLLFGEVTD SFITTASVNV TDNLAAFEES VDSIITFSIY YSYLGCGVLA LAYFQVVLWD
181: VAAERQIHKV RLRFFHAILR QEIAWFDVHK GGELNTRLAD DIDKIRNGIG DKLGIMLQYT
241: ATFVAGITIG FVKSWKLTLV ILAVSLILIV PLVGSTSVII QRMTKQALDA YAKAGAIAGE
301: VFSGIRTVVA FNGEEKEMVR YSSNLDQAKS KTVKKDFATL LAQGFLFFSM FSSYAIAFWY
361: GTVLYLDNEI TPGDILTTFL AVLFGAFAIG QAGPNYSDFT TARAAASSIW EVIDQIPTID
421: CFSTDGKKEK ITGQVTFEGV HFSYPSRASV KVLNGINLKV DVGKTVAMVG SSGCGKSTCI
481: QLIQRFYDVA EGSIKIDGID IRDLNVSWLR DHIGVVSQEP ILFATTIEEN IRYGRLDVTQ
541: VEIEKAAEEA NAHEFISKLP EGYSTLVGER GAQLSGGQKQ RIAIARALVR NPTILLLDEA
601: TSALDTESEA TVQLALEKAQ HGRTTLVIAH RLSTIFNSDL ICAFKEGIIS EQGTHEELMK
661: NEGGVYHTLV MKQGMKKEEE EEKKENEVPL DDDDDEEDDS QGEKVYRAGS GKKKLTRVLS
721: RTQSQMSGDE EKQDEDEYEK ELEKHFSMMR VWKLNTPECG FILLGCIGAA INGAVQPGFA
781: VVFSKILGAY SITDRAALFD EVTIYCVLFA ALGLLSLLAS IIQGVGFGKS GGELTLRLRN
841: MMFRAILRQN ISFFDDKRNG TGALTTKLAT DVSLIQGVTG VRLGMIFEVL FNIGVGIVIS
901: FVYSWQIACL LLFAFLPILS LAGMIGWKIL QGNSIGTAGS QAEVGKLVSE CIENIRTVQS
961: LNRGQTFHLK YCELQNPPYK QGIKGAFAAG LAFGFSQATI FFAYSATFRL GAHLVGTGDL
1021: TFPDVFLSFS ALMFGAFGLG RAAGSVPDFS KAKVATGELF YLVDRSPDID TFSDDGEKPA
1081: SYGGSVSLNN VRFRYPTRPD VPVLRGLSVS VDPGETLALV GSSGCGKSTT IQLMERFYDP
1141: HSGTVMFDSH DASLLNTRWQ RAQVGLVSQE PCLFDMSIAE NIKYGDNSRE VSIEDCIEAA
1201: KKSNIHDFVD SLPMKYDTNV GSKGTQLSGG QKQRIAIARA LVRNPKVLLL DEATSALDTE
1261: SERVVQDALD EAKKGRTCIT IAHRLSTIHN AEKIAVIREG KLAEFGKHEE LMAMKQQYYS
1321: LYTAQSMQH