3.A.1.201.20
12 TMS multidrug resistance transprter of 1318 aas, AbcB15 (Xiong et al. 2010) is the probable exporter of dichlorodiphenyltrichloroethane (DDT). Expression is induced by treatment with DDT, and this transporter appears to be responsible for DDT tolerance by pumping it out of the cell (Ning et al. 2014).
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| Accession Number: | I7LXH0 |
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| Protein Name: | ABC transporter family protein |
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| Length: | 1334 |
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| Molecular Weight: | 150120.00 |
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| Species: | Tetrahymena thermophila (strain SB210) [312017] |
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| Number of TMSs: | 9 |
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| Substrate |
drug, DDT |
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1: MEEKSLQNLE KPTQNYEDQE VADASKTDII LVVLGSLASV INGCLQPLFG LLFGEMAQKF
61: SPGYSADAVV DNCRTIALWF VGIGASNFFL VDNFDLIIMV EIRGQNMPTS FNNFVNVGQR
121: QAIKFRLEYF KSLLKQEVGY FDQIQANELS SKVSTECFKI QSALGEKTCI FIYSLSMFIG
181: SLIIAFIRGW QIALVAIAVT PLIASAGYFD QWVSEGIVKK TSSAYSSAGG ISEQAISAIR
241: TVKGLNGQDF EQNKYQSMIK KAFQVSLKFS IYEGVGLGLQ NMMFFFDFAL TFWVGSKFIE
301: DEVYNHNQGR SYNFSDVLTA FLAIMMSSFE LGQAMNSIKA FTQARQAGFN MFQILNRKSK
361: VDLNENGIDL TKKQINGEIK FENVDFSYPT HLDTKILKNL NISIQPHKKT AFVGESGRMY
421: LNFIFFKISG KSTIVQLIER FYDPQFGNIY LDGVNLKDFK LTSLRQSIGY VGQEPVLFAT
481: TIRENLLYGK RDATEEQMIE ALKQANAWQF IEKLEKGLDT YVGTSGAQFS GGQKQRISIA
541: RAILKNPKIL LLDEATSALD RKNEAQIQST LDSVSKGLTT IVVAHRLSTI QNSDEIIVLD
601: KGVVVERGTH DDLLKNNGAY FKFVEKQKII EKEQEKQAAH NNKTLCLLGE TQSRLASQSS
661: QTLNTEQEFL MKQESQNQNC QKLIQQFQNL NNIKEEDDDN DDEEAQNKAI RSSFSSQTQN
721: TPKQIEIVEQ NIIDLQNIQN TNVKQAQEKT NDQGIMKRLF SYNEKQTINY VLGFLFAIGN
781: GVCYPFSGYV LGKISDVLLD RTRSDFREQS NLQSLYFLIL GLAQLLTCTF QFYFFSRVAE
841: QLTFKLRKDL FQKYLKMPIS WFDHPHNTPG SLTQKLSTDC QAVNNMTSST LGIQLSNVSS
901: LVSALALAFS ADWRTTLVGL SLMPLMVLSQ AWYMSRMEGF GEKTDAAFRD STNMINEAAC
961: NIRTVTSFGN NQQLVQNFTQ ILDKNIKEIK KSALEAGLAI ACTNFILFAI YGTIFYAGST
1021: FHRDYDLSIV DMFISIQCLM FAAIGIGSNS HYLGDVGTSQ NAAKGIFQVL DSVDENQLNI
1081: LNFDNQDIHG EIQFKNVTFK YPQRDQIILK DVSFTIPAGQ KVAFVGPSGA GKSSIIQLIQ
1141: RFYDNYQGEI LLDGVDIKNY DLLKYRSKFG VVSQEPTLFT GTIKENIIYN TENVNEQQIE
1201: SITKQVNAYD FITNYSKNGV NGFDRQVGLK GNQLSGGQKQ RIAICRAMIK QPKIMLLDEA
1261: TSALDSQNEK IVQESLNEAM KQKTSICVAH RISTIKDSDM IYVMENGNIV EQGKYDQLMN
1321: LKNNFYKLQL GSSQ