3.A.1.201.25
MDR transporter, Crmdr1 of 1266 aas and 12 TMSs. Crmdr1 is constitutively expressed in the root, stem and leaf with lower expression in leaf. It has two transmembrane domains (TMDs) and two
nucleotide binding domains (NBDs) arranging in "TMD1-NBD1-TMD2-NBD2" direction (Jin et al. 2007).
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| Accession Number: | A5X7X7 |
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| Protein Name: | MDR-like ABC transporter |
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| Length: | 1266 |
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| Molecular Weight: | 137063.00 |
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| Species: | Catharanthus roseus (Madagascar periwinkle) [4058] |
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| Number of TMSs: | 12 |
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| Substrate |
drug |
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1: MKKSEDGAPN SPSSSKDNEK VPFLKLFSFA DGMDIALMII GTLGGIGNGL AQPIMTVILG
61: QLINTFGTNI YDKSEILHQV GQVSLKYVYL AIGAGMASFL QMSCWMVTGE RQATRIRGLY
121: LKTILRQDIG FFDTETSTGE VIGRMSGDTI LIQEAMGEKV GKFIQFSSTF IGGFLIAFIK
181: GWLLALVLTA CLPLLVATGA VMSLFMSKMA SQGQVAYAEA GNVLEQTVGG IRTVASFTGE
241: KLAIQKYNNK LKVAYRTTVK QGFASGAGFG TLLLVVFCIY GLAIYYGSRL IIEKGYNGGR
301: VINVMMAIMM GGMSLGQTSP SLSAFAAGQA AAYKMFETIK RKPQIDAYDT SGIVLEDIKG
361: EIELKDVYFR YPARPEVQIF SGFSLYVPSG TTAALVGQSG SGKSTVISLL ERFYDPEAGE
421: VLIDGVNLKK MRLRWLREQL GLVSQEPILF ATTIKENILY GKSNATDSEI RTAIQLANAA
481: KFIDKLPQGL DTMVGEHGTQ LSGGQKQRIA IARAILKNPR ILLLDEATSA LDAESERIVQ
541: DALDNVMSNR TTVVVAHRLS TIRNAHLIAV VQSGKLVEQG THAELIKDPN GAYSQLIRMQ
601: QGSKDTEDSR LLDVEKLDAE IDADETLMKS PSQRMSLRRS SSRGSSRKSF TFNYGIPGLV
661: EIHETEVGED EAEGDNTDIV SHKKVSFKRL AILNKPEIPQ LLLGSVAAII HGVIFPVFGL
721: LLSKSVRIMY EPPHQLRKDA RFWCLMYVGL GIITLLVLPL QNYFFGIAGG KLIERIRSLS
781: FEKVVHQEIS WFDDSKNSSG AVGARLSSDA STLRSLVGDA LALVVQNIAT VAAGLVISFT
841: ANWILALIIL AVLPLVGLQG FLQMKFYKGF SADAKVMYEE ASQVANDAVG SIRTVASFCA
901: EEKVMEMYQR KCEGPVKQGV RLGMVSGAGL GIGNGANYCA SAFCFYIGAV LVFHGKATFG
961: EVFRVFFALT MSAMGVSQAM ALAPDVNKTK QSAASVFEIL DAKPKIDSSS NKGQTLASVK
1021: GDIELQHISF KYPTRPDIQI FKGLCLSIPC GKTVALVGES GSGKSTVISL IERFYDPDSG
1081: NIYLDGVELQ KLKISWLRQQ MGLVSQEPVL FNESIRDNIA YGKQGNATED EIIAATKASN
1141: AHSFISSLPN GYDTSVGERG VQLSGGQKQR IAIARAILKD PRILLLDEAT SALDAESERI
1201: VQDALDKVMV NRTTVVVAHR LSTIKGADVI AVVKNGVISE KGRHDELMKM ENGVYASLVS
1261: LQSSAA