3.A.1.201.27
Multidrug resistance exporter of 1331 aas and 12 TMSs, TratrD or MDR2. Almost identical throughout must of its length to F2PRR1 from T equinum of 1235 aas and 12 TMSs (Martins et al. 2016). Displays increased levels of transcription of the TruMDR2 gene when mycelia were exposed to acriflavine, benomyl, ethidium bromide, ketoconazole, chloramphenicol, griseofulvin, fluconazole, imazalil, itraconazole, methotrexate, 4-nitroquinoline N-oxide (4NQO) or tioconazole. Disruption of the TruMDR2 gene rendered the mutant more sensitive to terbinafine, 4NQO and ethidium bromide than the control strain, suggesting that this transporter plays a role in modulating drug susceptibility in T. rubrum (Fachin et al. 2006).
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| Accession Number: | Q9HGT5 |
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| Protein Name: | Multidrug resistance protein MDR |
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| Length: | 1331 |
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| Molecular Weight: | 145284.00 |
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| Species: | Trichophyton rubrum (Athlete's foot fungus) [5551] |
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| Number of TMSs: | 12 |
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| Substrate |
drug |
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1: MVEVSEKPNT QDDGVSKQEN RNPASSSSST SDKEKVAKKG NSDATKSSTP EDLDAQLAHL
61: PEHEREILKQ QLFIPDAKAT YGTLFRYATR NDMIFLAIVS LASIAAGAAL PLFTVLFGSL
121: AGTFRDIALH RITYDEFNSI LTRNSLYFVY LGIAQFILLY VSTVGFIYVG EHITQKIRAK
181: YLHAILRQNI GFFDKLGAGE VTTRITADTN LIQDGISEKV GLTLTALSTF FSAFIIGYVR
241: YWKLALICSS TIVAMILVMG GISRFVVKSG RMTLVSYGEG GTVAEEVISS IRNATAFGTQ
301: EKLARQYEVH LKEARKWGRR LQMMLGIMFG SMMAIMYSNY GLGFWMGSRF LVGGETDLSA
361: IVNILLAIVI GSFSIGNVAP NTQAFASAIS AGAKIFSTID RVSAIDPGSD EGDTIENVEG
421: TIEFRGIKHI YPSRPEVVVM EDINLVVPKG KTTALVGPSG SGKSTVVGLL ERFYNPVSGS
481: VLLDGRDIKT LNLRWLRQQI SLVSQEPTLF GTTIFENIRL GLIGSPMENE SEEQIKERIV
541: SAAKEANAHD FIMGLPDGYA TDVGQRGFLL SGGQKQRIAI ARAIVSDPKI LLLDEATSAL
601: DTKSEGVVQA ALDAASRGRT TIVIAHRLST IKSADNIVVI VGGRIAEQGT HDELVDKKGT
661: YLQLVEAQKI NEERGEESED EAVLEKEKEI SRQISVPAKS VNSGKYPDED VEANLGRIDT
721: KKSLSSVILS QKRSQEKETE YSLGTLIRFI AGFNKPERLI MLCGFFFAVL SGAGQPVQSV
781: FFAKGITTLS LPPSLYGKLR EDANFWSLMF LMLGLVQLVT QSAQGVIFAI CSESLIYRAR
841: SKSFRAMLRQ DIAFFDLPEN STGALTSFLS TETKHLSGVS GATLGTILMV STTLIVALTV
901: ALAFGWKLAL VCISTVPVLL LCGFYRFWIL AQFQTRAKKA YESSASYACE ATSSIRTVAS
961: LTREQGVMEI YEGQLNDQAK KSLRSVAKSS LLYAASQSFS FFCLALGFWY GGGLLGKGEY
1021: NAFQFFLCIS CVIFGSQSAG IVFSFSPDMG KAKSAAADFK RLFDRVPTID IESTDGEKLE
1081: TVEGTIEFRD VHFRYPTRPE QPVLRGLNLT VKPGQYIALV GPSGCGKSTT IALVERFYDT
1141: LSGGVYIDGK DISRLNVNSY RSHLALVSQE PTLYQGTIRD NVLLGVDRDD VPDEQVFAAC
1201: KAANIYDFIM SLPDGFGTVV GSKGSMLSGG QKQRIAIARA LIRDPKVLLL DEATSALDSE
1261: SEKVVQAALD AAAKGRTTIA VAHRLSTIQK ADIIYVFDQG RIVESGTHHE LLQNKGRYYE
1321: LVHMQSLEKT Q