3.A.1.201.28
MDR1 alkaloid/multiple drug efflux transporter of 1292 aas and 12 TMSs (Shitan et al. 2003).
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| Accession Number: | I0J0H5 |
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| Protein Name: | ABC protein |
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| Length: | 1292 |
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| Molecular Weight: | 139619.00 |
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| Species: | Coptis japonica (Japanese goldthread) [3442] |
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| Number of TMSs: | 12 |
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| Substrate |
alkaloid |
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1: MAEENGFNGD QNNHLQATAS TSHSPAKLTN KTSGSTKSDQ QDSDKGEGVE KMSAETVPYY
61: KLFSFADSKD LVLMVIGTIA SVANGASMPI MTFLVGDLIN AFGQNANNKN TLPVVSRVAL
121: RFVYLAVGAG VASVFQVACW MVTGERQASR IRSLYLKTIL RQDVAFFDKE TNTGEVVGRM
181: SGDIVRIQDA MGEKVGKFIQ LFSTFIGGFI VAFVRGWLLT LIMLSSIPVL VISGAFVTIV
241: VSKMASRGQA AYSQAAITVE QTIGSIRTVA SFSGEKHAIT QYEKSLQKAY KSGVHEGLAS
301: GLGLGASMLI FFCSYALAIW FGGRMIIEKD YTGGDIINII DAILVGSFSL GQASPCLSAF
361: AAGQAAAFKM FETIKRKPEI DSYDTKGRVL DDIHGDIELK DICFSYPARP DEQIFSGFSL
421: SLPSGTTSAL VGESGSGKST VISLIERFYD PQAGEVLIDG INLKEFQLRW IRQKIGLVSQ
481: EPVLFASSIK DNIAYGKDGA TLEDIKAAAE LANAAKFIDK LPQGLDTLVG EHGTHLSGGQ
541: KQRVAIARAI LKDPRILLLD EATSALDAES EHIVQEALDR VMVNRTTVVV AHRLSTIRSA
601: DMIAVVHRGK IVEKGSHSEL LKDPDGAYSQ LIRLQEVNRS SENKAESTEF GRSSSHQQSF
661: RRSMSRGSSG VGNSSRKSFS MSFGLPTPHI PEVVSAKPES TPEPKKQTEE VPLLRLASLN
721: KPEIPILLLG AISAAINGLI FPIFGVLLAS VIKTFYKPED ELRKDSRFWA LMFIVLGIAS
781: FVASPAGTYF FSVAGCRLIQ RIRSMCFEKV VHMEINWFDE PEHSSGAIGA KLSSDAASVR
841: SLVGDALSLL VQNAASAIAG LAIAFEANWI LALIILVLLP LIGLNGYLQT KFMTGFSADA
901: KMMYEEASQV ASDAVGSIRT VASFCAEEKV MQLYKKKCEG PMKTGIRQGL ISGIGFGVSF
961: FLLYNVYATS FYVGARLVED GKTTFAEVFR VFFALTMAAL GISQSSSFAP DSSKARASTA
1021: SIYGILDRKS KIDSSDDSGI TLENLNGDIE LRHVSFKYST RPDIQILRDL SLAIRSGKTV
1081: ALVGESGSGK STVISLLQRF YDPDSGYITL DGVEIQKLQL RWLRQQMGLV SQEPVLFNET
1141: IRANIAYGKE GDATETEILA AAELANAHKF ISALQQGYDT MVGERGVQLS GGQKQRVAIA
1201: RAMVKAPKIL LLDEATSALD AESERVVQDA LDKVMVNRTT IVVAHRLSTI KNADLIAVVK
1261: NGVIVEKGKH DHLINISDGV YASLVALHMT AS