3.A.1.201.39
Multidrug resistance-1, Mdr1, of 1464 aas and 12 TMSs in a 6 +6 TMS arrangement (domain order: M-C-M-C). Confers resistance to chloroquine (CQ) and primaquine (PQ), but mutations decrease resistance (Kittichai et al. 2018).
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| Accession Number: | Q672L3 |
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| Protein Name: | Mdr1 |
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| Length: | 1464 |
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| Molecular Weight: | 165406.00 |
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| Species: | Plasmodium vivax [5855] |
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| Number of TMSs: | 15 |
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| Substrate |
drug |
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1: MKKDQRQPRD NSNSSNNLSI KDEVEKELNK KGTFELYKKI KTQKIPFFLP FKCLPSSHRK
61: LLGVSFVCAT ISGGTLPFFV SVFGVIMKNM NLGENVNDII FSLVLIGIFQ FILSFISSFC
121: MDVVTTKILK TLKIEFLKSV FYQDGQFHDN NPGSKLTSDL DFYLEQVNAG IGTKFITIFT
181: YASAFLGLYI WSLFKNARLT LCITCVFPLI YICGVICNKK VKINKKTSLL YNNNTMSIIE
241: EALVGIRTVV SYCGENTILK KFNLSEKLYS KYTLKANLME SLHIGMINGF ILASYAFGFW
301: YGTRIIISDL SNQQPNNDFH GGSVISILLG VLISMFMLTI ILPNITEYMK SLEATNNLYE
361: IINRKPLVEN NQDGKKLKDI KKIQFKNVRF HYDTRKDVEI YKDLNFTLTE GKTYAFVGES
421: GCGKSTILKL IERLYDPTEG DVIINDSHNL KDVNLKWWRS KIGVVSQDPL LFSNSIKNNI
481: KYSLYSLKDL EALSEESNED GFSSQSDSNS RNSCRAKCAG DLNDMIQTTD STELIQVRKN
541: YETIEDSEVV SVSKKVLIHD FVSALPDKYE TLVGSNASKL SGGQKQRISI ARAIIRNPKI
601: LILDEATSSL DNKSEYLVQK TINNLKGNEN RITIIIAHRL STIRYANTIF VLSNRENGST
661: VDVDVLGEDP TKDSNEKNEK HDKQEKGGKN SSANQKIGNA GSYIIEQGTH DALMKNKNGI
721: YYTMINNQKV SSKSSSNNDN DKDSDMKSSI YKDSERGYDP DEANGNAKNE SASAKKSEKM
781: SDAKASNTNA GGRLAFLRNL FKRKPKAPNN LRVVYREIFS YKKDIAIIAL SIMVAGGLYP
841: LFALLYAKYV GTLFDFANLE ANSNKYSLYI LVIAIAMFIS ETLKNYYNNV IGEKVEKTMK
901: LRLFENILYQ EISFFDQDSH APGLLSAHIN RDVHLLKTGL VNNIVIFTHF IVLFLVSMVM
961: SFYFCPIVAA VLTGTYFIFM RVFAIRARIA ANKDVEKKRV NQPGTAFVYN SDDEIFKDPS
1021: FLIQEAFYNM NTVIIYGLED YFCTLIEKAI DYSNKGQKRK TLINSMLWGF SQSAQFFINS
1081: FAYWFGSFLI RRGTIQVDDF MKSLFTFLFT GSYAGKLMSL KGDSENAKLS FERYYPLITR
1141: KSLIDVRDNG GIKIKNSNDI KGKIEIMDVN FRYLSRPNVP IYKDLTFSCE SKKTTAIVGE
1201: TGSGKSTVMS LLMRFYDLKN DHHIVFKNEQ TGESSKEQMQ QGDEEQNVGM KNANEFSSSK
1261: EGADGQSSTL FKNSGKILLD GVDICDYNLK DLRNLFSIVS QEPMLFNMSI YENIKFGKEN
1321: ATREDVKRAC KFAAIDEFIE SLPNQYDTNV GPYGKSLSGG QKQRIAIARA LLREPKILLL
1381: DEATSSLDSN SEKLIEKTIV DIKDKADKTI ITIAHRIASI KRSDKIVVFN NPDRTGSFVQ
1441: AQGTHEELLS VQDGVYKKYV KLAK